You examine a male patient and find an enlarged prostate on a digital rectal examination. He complained of having difficulty with erectile dysfunction and urine flow. What appropriate treatment would be prescribed?

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Advanced Pharmacology Across the Lifespan Questions

Question 1 of 5

You examine a male patient and find an enlarged prostate on a digital rectal examination. He complained of having difficulty with erectile dysfunction and urine flow. What appropriate treatment would be prescribed?

Correct Answer: B

Rationale: The correct answer is B: A daily low dose of oral tadalafil. This is the appropriate treatment because tadalafil is a phosphodiesterase type 5 inhibitor that is commonly used for both erectile dysfunction and benign prostatic hyperplasia (enlarged prostate). A low daily dose of tadalafil can help improve both erectile function and urine flow in patients with an enlarged prostate. A: Oral tadalafil as needed may not provide consistent relief for urinary symptoms associated with an enlarged prostate. C: Sildenafil is another phosphodiesterase type 5 inhibitor but is not as effective for treating an enlarged prostate compared to tadalafil. D: Topical minoxidil is used for hair loss and is not indicated for the symptoms described in the patient scenario.

Question 2 of 5

What do drug blood levels indicate?

Correct Answer: D

Rationale: The correct answer is D because drug blood levels indicate if the amount of drug in the body is within a therapeutic range, ensuring the drug is effective and safe. Choice A is incorrect because blood levels do not confirm the drug's specific form. Choice B is incorrect as body fat does not directly relate to drug metabolism. Choice C is incorrect as blood levels do not verify medication ownership.

Question 3 of 5

Which of the following drugs was most likely given?

Correct Answer: C

Rationale: The correct answer is C: Flucytosine. Flucytosine is an antifungal medication used to treat fungal infections like cryptococcal meningitis. The other options, Fluorouracil and Cytarabine, are chemotherapy drugs used for cancer treatment. Griseofulvin is an antifungal medication used to treat fungal skin infections. Flucytosine is the most likely drug given in this scenario due to its specific indication for fungal infections, which aligns with the patient's symptoms.

Question 4 of 5

Which of the following enzymes most likely mediated the therapeutic effect of terbinafine in the patient's disease?

Correct Answer: C

Rationale: The correct answer is C: Squalene epoxidase. Terbinafine is an antifungal drug that inhibits squalene epoxidase, a key enzyme in the ergosterol biosynthesis pathway in fungi. Inhibition of squalene epoxidase disrupts fungal cell membrane synthesis, leading to cell death. Thymidylate synthase (A) is involved in DNA synthesis, not the target of terbinafine. Lanosterol synthetase (B) is not a direct target of terbinafine. Transpeptidase (D) is an enzyme targeted by antibiotics like penicillin, not terbinafine. In summary, squalene epoxidase is the correct choice as it is the specific target of terbinafine in fungal cells, distinguishing it from the other options.

Question 5 of 5

Which of the following medications is used to treat depression by inhibiting the reuptake of both serotonin and norepinephrine?

Correct Answer: B

Rationale: Step 1: Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Step 2: SNRIs work by blocking the reuptake of both serotonin and norepinephrine in the brain. Step 3: By inhibiting the reuptake of these neurotransmitters, duloxetine helps increase their levels in the brain, which can improve mood and alleviate depression. Step 4: Therefore, duloxetine is the correct choice for a medication that treats depression by inhibiting the reuptake of both serotonin and norepinephrine. Summary: A: Fluoxetine is a selective serotonin reuptake inhibitor (SSRI), not affecting norepinephrine. C: Sertraline is also an SSRI, not targeting norepinephrine reuptake. D: Venlafaxine is an SNRI like duloxetine, but it specifically targets serotonin and norepinephrine reuptake, making

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