ATI RN
ATI Pharmacology Book Questions
Question 1 of 5
A drug for which research has shown an adverse effect in animals but not in pregnant women would be categorized as Category
Correct Answer: C
Rationale: Category C drugs show animal adverse effects (e.g., fetal harm) but lack human data, fitting this scenario-risk can't be ruled out. Category A is safe in humans. B has no animal or human risk. D has human risk evidence. C balances uncertainty, per FDA.
Question 2 of 5
An intrinsic activity of < 1 is exhibited by.
Correct Answer: D
Rationale: An intrinsic activity of < 1 is exhibited by a partial agonist. Intrinsic activity, also known as efficacy, refers to the ability of a drug to activate a receptor upon binding. A partial agonist has lower intrinsic activity compared to a full agonist. It is able to activate the receptor, but to a lesser extent, often resulting in a submaximal response even when all receptors are occupied. This characteristic of partial agonists makes them important in pharmacology for providing a more controlled and graded response compared to full agonists.
Question 3 of 5
A 17-year-old man is brought to the emergency department with severe right lower quadrant pain that he first felt around his umbilicus. His white blood cell count is 12,000/μL of blood. He is taken to the operating room for emergent laparoscopic appendectomy. About an hour into the surgery, his body temperature spikes and CO2 production rises uncontrollably. What is the next step in the treatment of this patient?
Correct Answer: C
Rationale: Fever and CO2 rise during surgery suggest malignant hyperthermia (MH). Dantrolene , a ryanodine receptor antagonist, halts MH by blocking calcium release. Acetaminophen reduces fever but not MH. Bromocriptine treats neuroleptic syndrome. Diazepam and Naproxen (E) are irrelevant. Dantrolene's specificity saves lives in this surgical emergency.
Question 4 of 5
Which of the following drugs is more likely to cause hyperkalaemia than hypokalaemia in a patient with diabetes and estimated glomerular filtration rate (eGFR) within the 'normal' reference range?
Correct Answer: D
Rationale: Hyperkalemia involves elevated potassium, hypokalemia reduced levels. Amphotericin causes hypokalemia via renal potassium wasting, not hyperkalemia. Prednisolone, a glucocorticoid, promotes potassium excretion, risking hypokalemia. Low molecular weight heparin (LMWH) rarely affects potassium directly with normal eGFR. Salmeterol, a beta-agonist, can shift potassium intracellularly, causing hypokalemia. Insulin, in diabetes management, drives potassium into cells with glucose, potentially causing hyperkalemia if renal excretion is impaired, though less common with normal eGFR. However, its potassium-shifting effect makes hyperkalemia more likely than hypokalemia compared to others, especially in acute settings, a key consideration in diabetic care.
Question 5 of 5
A patient who is taking aspirin for arthritis pain asks the nurse why it also causes gastrointestinal upset. The nurse understands that this is because aspirin:
Correct Answer: C
Rationale: Aspirin works by inhibiting both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. COX-1 is responsible for producing prostaglandins that help maintain the stomach lining, promote blood clotting, and support kidney function. When COX-1 is inhibited by aspirin, it interferes with the protective mechanisms of the stomach lining, leading to increased risk of gastrointestinal irritation, ulcers, and bleeding. This is why aspirin is known to cause gastrointestinal upset, including symptoms like stomach pain, heartburn, nausea, and even ulcers in some cases.