ATI RN
ATI Pharmacology Assessment 2 Questions
Question 1 of 5
Which of the following combinations of antiparkinsonian drugs is appropriate treatment plan?
Correct Answer: B
Rationale: Levodopa, the cornerstone of Parkinson's treatment, converts to dopamine in the brain. Carbidopa inhibits peripheral dopa decarboxylase, increasing levodopa's CNS availability and reducing side effects. Entacapone, a COMT inhibitor, prolongs levodopa's half-life by preventing its peripheral breakdown, enhancing efficacy. This trio targets dopamine synthesis and metabolism synergistically, a standard advanced-stage regimen. Amantadine lacks synergy with carbidopa/entacapone, focusing on NMDA antagonism. Pramipexole (dopamine agonist) with carbidopa/entacapone is less common, as carbidopa pairs with levodopa. Ropinirole and selegiline boost dopamine but miss levodopa's direct effect; entacapone's role weakens without levodopa. The levodopa-carbidopa-entacapone combination optimizes dopamine delivery, making it a clinically proven and appropriate plan.
Question 2 of 5
Local vasoconstriction is of short duration and can be prolonged by application of:
Correct Answer: C
Rationale: Thromboxane is a vasoconstrictor that is released by platelets during the process of blood clotting. Local vasoconstriction is a temporary response that occurs to reduce bleeding at the site of injury. Thromboxane plays a role in this process by constricting the blood vessels temporarily to limit blood flow to the injured area. By prolonging the application of thromboxane, vasoconstriction can be prolonged to support the clotting process and minimize bleeding. Adrenaline, steroids, heparin, and thrombin do not have the same vasoconstrictive properties as thromboxane.
Question 3 of 5
Toxicity of nicotine containing products:
Correct Answer: D
Rationale: Nicotine toxicity can cause neuromuscular blockade (late phase), but atropine treats muscarinic effects, not paralysis, so that's false. It causes hypertension initially via catecholamine release, not hypotension, making that false. It harms the fetus (e.g., growth restriction), so that's incorrect. Benzodiazepines control agitation and seizures symptomatically, a true statement, useful in acute poisoning. Nausea/vomiting resolve faster than days. Benzodiazepines' symptomatic relief is a practical approach, addressing CNS overstimulation in nicotine overdose.
Question 4 of 5
Colchicine is prescribed for a client with gout. The nurse reviews the client’s record, knowing that this medication would be used in caution in which of the following medical conditions?
Correct Answer: B
Rationale: Colchicine should be used with caution in patients with aplastic anemia or other blood dyscrasias, as it can exacerbate bone marrow suppression. While colchicine is used to treat conditions like Behcet disease and familial Mediterranean fever, it is not contraindicated in these conditions. Amyloidosis is not a primary concern with colchicine use. Monitoring blood counts is essential in patients with pre-existing hematologic conditions.
Question 5 of 5
A 21-year-old male presents to the clinic with 6 weeks of painful, bloody stools. Flexible sigmoidoscopy reveals erythema and friability with pseudopolyps. Which of the following drugs used for ulcerative colitis has both anti-inflammatory and antibacterial properties?
Correct Answer: C
Rationale: Ulcerative colitis (U
C) presents with bloody stools and mucosal inflammation, as seen on sigmoidoscopy. Sulfasalazine is correct-it combines 5-ASA (anti-inflammatory) and sulfapyridine (antibacterial), reducing inflammation and bacterial overgrowth in UC. Azathioprine is an immunosuppressant, lacking antibacterial action. Cyclosporine is immunosuppressive, not antibacterial. Mesalamine is anti-inflammatory only. Olsalazine (E) is similar to mesalamine. Sulfasalazine's dual action targets UC's inflammatory and microbial components, making it uniquely suited among the options for this chronic condition.