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Question 1 of 5
Which form of human plague is present with high fever and large lymphadenopathies (buboes). The case fatality in untreated cases may reach 60%.
Correct Answer: A
Rationale: The correct answer is A: Bubonic plague. Bubonic plague is characterized by high fever and large swollen lymph nodes (buboes). The case fatality rate in untreated cases can reach 60%. This form of plague is typically transmitted through the bite of an infected flea.
B: Pneumonic plague presents with respiratory symptoms and is transmitted through respiratory droplets.
C: Gastrointestinal plague is not a recognized form of plague.
D: Septicemic plague is a severe form of plague where the bacteria multiply in the bloodstream. It may not always present with buboes.
Question 2 of 5
The term “zone of inhibition†is used in which of the following procedures?
Correct Answer: C
Rationale: The correct answer is C: Disk-diffusion test. In the disk-diffusion test, the zone of inhibition refers to the area around an antimicrobial disk where bacterial growth is inhibited. This test is used to determine the susceptibility of bacteria to specific antibiotics. The other choices, such as A: Use-dilution test, B: Growth inhibition test, and D: Multiple inhibition test, do not specifically involve measuring the zone of inhibition and are not commonly used methods for testing antibiotic susceptibility.
Question 3 of 5
After a prolonged isoniazid treatment, the patient developed polyneuritis, paresthesia, memory disorders, and convulsions. What is the most likely mechanism of the described isoniazid side-effects?
Correct Answer: D
Rationale: The correct answer is D. Isoniazid inhibits pyridoxal phosphate synthesis, which is the active form of vitamin B6. Pyridoxal phosphate is essential for various enzymatic reactions, including neurotransmitter synthesis and myelin formation.
Therefore, isoniazid-induced pyridoxal phosphate deficiency can lead to neurological symptoms like polyneuritis, paresthesia, memory disorders, and convulsions.
A: Disruption of cell membrane synthesis - This is not the mechanism of isoniazid side-effects.
B: Inhibition of protein synthesis - Isoniazid does not directly inhibit protein synthesis.
C: Inhibition of RNA-synthesis - Isoniazid does not inhibit RNA synthesis; it affects vitamin B6 metabolism.
Question 4 of 5
Which of the following pathogens can cause meningitis?
Correct Answer: C
Rationale: Rationale for choice C (Strep. pneumoniae):
1. Strep. pneumoniae is a common cause of bacterial meningitis.
2. It is a leading pathogen responsible for meningitis in adults and children.
3. It can invade the bloodstream and reach the meninges, causing inflammation.
4. Treatment guidelines often include antibiotics effective against Strep. pneumoniae.
Summary of why other choices are incorrect:
A. Staph. aureus is not a common cause of meningitis.
B. Strep. pyogenes typically causes streptococcal infections but not meningitis.
D. "None of the above" is incorrect as Strep. pneumoniae can cause meningitis.
Question 5 of 5
Which of the following statements is FALSE regarding B cells?
Correct Answer: B
Rationale: B cells develop in the bone marrow, not the thymus. Firstly, hematopoietic stem cells in the bone marrow give rise to B cells. They undergo maturation and selection processes in the bone marrow, not in the thymus.
Therefore, choice B is false. On the other hand, choices A, C, and D are correct. A is true because B cells with high affinity to self-antigens undergo apoptosis to prevent autoimmunity. C is true since B cells synthesize antibodies which can be displayed on their surface as B cell receptors. D is true because B cells can undergo class switching to produce different types of antibodies based on the immune response requirements.
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