ATI RN
Pharmacology Final ATI Questions
Question 1 of 5
A 65-year-old man with end-stage renal disease because of diabetes recently underwent a renal transplant. He has been responding well to the transplant and his creatinine has stabilized around 2.1 mg/dL. He was placed on immunosuppressive therapy with muromonab. What is the mechanism of action of muromonab?
Correct Answer: A
Rationale: Muromonab (OKT3) prevents transplant rejection by binding CD3 on T cells . This depletes and inactivates T cells. FK-binding , IL-2 receptor , mTOR , and calcineurin (E) are other drugs' mechanisms. CD3 targeting ensures immunosuppression in this patient.
Question 2 of 5
Which explanation best indicates why barbiturates are rarely used to treat anxiety and insomnia?
Correct Answer: D
Rationale: Barbiturates (e.g., phenobarbital) cause serious adverse effects-respiratory depression, dependence-limiting use versus safer options like benzos, per pharmacology. Cost isn't higher. Allergies aren't notable. They're effective but risky. Side effects drive rarity, a safety shift.
Question 3 of 5
A 52-year-old man with organic impotence is in the preoperative holding area before surgery. He is given intravenous vancomycin over 20 min and begins to develop fever, chills, and redness at the injection site. What is the most appropriate course of action for the physician to take?
Correct Answer: D
Rationale: Vancomycin's rapid infusion causes red man syndrome (fever, chills, redness) is discontinue . Anticholinesterase is irrelevant. Corticosteroids treat severe reactions, not initial step. Intubation is excessive. Slowing infusion (E) is preventive, not reactive. Stopping vancomycin halts histamine release, resolving symptoms.
Question 4 of 5
Which of the following is not a phenylpropionic derivatives:
Correct Answer: D
Rationale: Mefenamic acid is not a phenylpropionic derivative. It is classified as a fenamate, structurally related to fenamic acid. The other options (A. ibuprofen, B. fenoprofen, C. naproxen) are all examples of phenylpropionic derivatives, commonly referred to as propionic acids. These drugs have similar chemical structures and mechanisms of action, making them a distinct group within the nonsteroidal anti-inflammatory drug (NSAI
D) class.
Question 5 of 5
A patient is receiving TPN at home. The visiting nurse assists the family with the care plan, which includes changing the TPN solution and tubing. What is the recommended initial frequency for changing the tubing?
Correct Answer: A
Rationale: TPN tubing should be changed every 24 hours to prevent infection and maintain sterility. Longer intervals (B, C,
D) increase the risk of bacterial contamination and sepsis.