Correct Answer: D

Rationale: The correct answer is D: Dry and rough. In hypothyroidism, there is reduced secretion of sweat and oils, leading to dry skin. The lack of hydration causes the skin to become rough. This correlates with the clinical presentation of fatigue, weight gain, and hair loss, which are common symptoms of hypothyroidism. Choices A and B are incorrect because moisture is reduced in hypothyroidism, resulting in dry skin. Choice C is incorrect because the lack of oils in hypothyroidism leads to rough skin texture, not smooth.

Correct Answer: D

Rationale: The correct answer is D, "All of the above." Bill's symptoms of epigastric pain lasting 30 minutes or more can be indicative of peptic ulcer, pancreatitis, or myocardial ischemia. Peptic ulcer can cause epigastric pain, pancreatitis presents with severe epigastric pain, and myocardial ischemia can manifest as epigastric discomfort. Considering all these possibilities is crucial for proper diagnosis and treatment. The other choices are incorrect because they do not encompass all potential causes of Bill's symptoms. It is important to consider a broad differential diagnosis to ensure comprehensive evaluation and management.

Correct Answer: D

Rationale: The correct answer is D, cardiomyopathy. Cardiomyopathy is a disease of the heart muscle that can lead to an increase in the size and strength of the heart muscle, resulting in an increased amplitude of the apical impulse. This is due to the heart working harder to pump blood effectively. Hypothyroidism (choice A) typically does not cause an increase in the amplitude of the apical impulse. Aortic stenosis (choice B) and mitral stenosis (choice C) both result in pressure or volume overload on specific chambers of the heart, but they do not directly lead to diffuse and increased amplitude of the apical impulse like cardiomyopathy does. In summary, an increase in the amplitude of the apical impulse is more likely to be caused by cardiomyopathy due to the increased workload on the heart muscle, compared to the other conditions provided in the choices.

Correct Answer: B

Rationale: The correct answer is B: Clonus. Clonus is a series of rhythmic, involuntary muscle contractions and relaxations that occur due to an abnormal response in the stretch reflex. In patients with neurological conditions like cerebral palsy, clonus is often observed due to increased muscle tone. Tremor (A) is a rhythmic shaking movement, not specifically associated with muscle contractions. Spasm (C) is a sudden, involuntary muscle contraction that is not typically rhythmic. Fasciculation (D) is a brief, spontaneous contraction of a small number of muscle fibers, not the rhythmic pattern seen in clonus.

Correct Answer: B

Rationale: The correct answer is B: One breast larger than the other is most likely benign on breast examination. This is because breast asymmetry is a common and typically benign finding in women. It is important to note that a significant difference in breast size may warrant further evaluation, but in general, slight variations in size are normal. Now, let's discuss why the other choices are incorrect: A: Dimpling of the skin resembling that of an orange is concerning for peau d'orange appearance, which can be a sign of underlying breast cancer. C: One nipple inverted can be a sign of an underlying breast issue, such as a mass or tumor. D: One breast with a dimple when the patient leans forward can be a sign of an underlying breast abnormality, such as a tumor pulling on the skin. In summary, breast asymmetry (Choice B) is the most likely benign finding, while the other choices may indicate underlying breast issues that require further evaluation.