ATI RN
Pediatric Genetic Questions
Question 1 of 5
Why is sickle cell disease so called?
Correct Answer: C
Rationale: Sickle cell disease is named for the sickle-shaped red blood cells caused by abnormal hemoglobin under low oxygen (not strictly pH), leading to their characteristic shape.
Question 2 of 5
A particular allele can have different effects if it was inherited from a male rather than a female. This phenomenon is known as:
Correct Answer: B
Rationale: Genomic imprinting causes differential expression of alleles based on parental origin (e.g., Prader-Willi vs. Angelman syndromes).
Question 3 of 5
In normal differentiated somatic cells, telomerase:
Correct Answer: B
Rationale: Telomerase is inactive in most somatic cells, leading to telomere shortening with each division, unlike cancer cells where it’s often active.
Question 4 of 5
Chronic myeloid leukemia is caused by a translocation that creates:
Correct Answer: D
Rationale: The BCR-ABL fusion protein from t(9;22) is a tyrosine kinase that deregulates myeloid cell proliferation.
Question 5 of 5
The main gatekeeper for FAP colon cancer is most likely:
Correct Answer: A
Rationale: APC (adenomatous polyposis coli) is the primary gatekeeper gene in familial adenomatous polyposis, initiating polyp formation when mutated.