ATI RN
Lymphatic System Quiz Questions Questions
Question 1 of 5
Which type of T cell has limited TCR diversity?
Correct Answer: A
Rationale: NKT cells have limited TCR diversity ; gamma-delta and alpha-beta T cells have broader repertoires.
Question 2 of 5
Which of these does not belong with the others?
Correct Answer: A
Rationale: Thymus is a primary lymphoid organ; lymph node , sinus , and nodule are secondary lymphoid structures.
Question 3 of 5
Individuals with defects in T cell development have a severe immunodeficiency disease called SCID (severe combined immunodeficiency disease). In these individuals, the absence of all T cells causes defects in both cell-mediated (T cell-based) and humoral (antibody-based) immune responses. The defect in antibody responses in SCID patients is due to:
Correct Answer: D
Rationale: T follicular helper cells are critical for antibody responses; B-cell development is T-independent, organs form , phagocytes exist , B cells survive .
Question 4 of 5
Many different viruses encode proteins that function to down-regulate MHC class I expression on host cells following infection with the virus. This immune evasion mechanism allows the virus to hide from CD8 T lymphocytes that normally detect virus-infected cells by using their T cell antigen receptor to recognize viral peptides bound to MHC class I proteins on the surface of the infected cell. To counteract this immune evasion strategy, NK cells have:
Correct Answer: A
Rationale: NK cells use inhibitory MHC I receptors ; low MHC I activates them, not activating MHC or capsid (C/D) receptors.
Question 5 of 5
The TCR signaling module leading to transcription factor activation is dependent on the enzyme phospholipase-C-γ (PLC-γ). The mechanism by which PLC-γ activates multiple transcription factors is by:
Correct Answer: A
Rationale: PLC-γ produces IP3 and DAG , activating transcription factors; not direct cleavage , nuclear diffusion , or chaperones .