ATI RN
Pharmacology ATI Quizlet Questions
Question 1 of 5
Which statement is false:
Correct Answer: C
Rationale: Higher potency (lower dose for effect) can coexist with lower efficacy (max effect), true, as potency reflects affinity, not ceiling effect. Higher receptor affinity increases potency, true, per receptor theory. Lower potency doesn't mandate lower efficacy; a less potent drug can achieve the same max effect with more dose, making this false. Higher potency with equal efficacy is true (e.g., partial agonists). This pharmacodynamic distinction is vital for drug selection, where efficacy often trumps potency.
Question 2 of 5
The home health nurse notes that the elderly patient doubled up on his pain medication, even though the prescribed dose was at a therapeutic level. The patient says, 'If one pill is good, two pills are better.' Which statement best describes the result of the patient's action?
Correct Answer: D
Rationale: Doubling a therapeutic dose exceeds the plateau-efficacy maxes out, but side effects (e.g., sedation) rise with excess, especially in the elderly with slower clearance. Tolerance needs chronic use, not one event. More relief assumes linear gain, not true. Tolerance requiring more is future, not immediate. Side effects reflect pharmacodynamics, a key risk.
Question 3 of 5
A patient taking which of the following medications should avoid foods high in tyramine?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
A 59-year-old man with hypertension, gastroesophageal reflux disorder, AIDS, seizure disorder, and depression is currently maintained on multiple medications, including propranolol. He does not have his medication list at his current office visit with his primary care physician. His blood pressure is 180/100 mm Hg. The patient states that he is taking all of his medications as scheduled. Which of the following drugs is the most likely explanation of this finding?
Correct Answer: D
Rationale: The patient's uncontrolled hypertension (180/100 mm Hg) despite propranolol, a β-blocker, suggests a drug interaction. Cimetidine , an H2 blocker, inhibits CYP2D6, but propranolol's metabolism is via CYP1A2/CYP2D6-effect is minimal. Fluoxetine and Paroxetine , SSRIs, also inhibit CYP2D6, but their impact on propranolol is less significant. Rifampin induces CYP enzymes, reducing propranolol levels, but isn't listed as likely. Ritonavir (E), a protease inhibitor for AIDS, potently inhibits CYP3A4 and CYP2D6, increasing propranolol levels, yet here it paradoxically fails to control BP, possibly due to complex polypharmacy or adherence issues. Ritonavir's interaction is most likely given his AIDS treatment, affecting propranolol's efficacy or metabolism, leading to this outcome.
Question 5 of 5
A 64-year-old alcoholic man who has not had access to alcohol for days is brought to the hospital by family. He is extremely agitated and reports seeing spiders on the walls that he wants to kill. His temperature is 39°C, pulse is 96 beats/minute, and blood pressure is 152/88 mm Hg. He is given a benzodiazepine, which mimics the effects of alcohol on his brain. Which of the following types of receptor to benzodiazepines is acted upon?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.