ATI RN
Principles of Pharmacology Questions
Question 1 of 5
Which one of the following is characteristic of parasympathetic stimulation?
Correct Answer: B
Rationale: The correct answer is B: Increase of bronchial secretion. Parasympathetic stimulation activates the vagus nerve, leading to bronchial smooth muscle relaxation and increased secretion to facilitate breathing. This response helps in clearing the airways and optimizing gas exchange. Choices A, C, and D are incorrect because parasympathetic stimulation typically does not lead to an increase in intestinal motility (A), contraction of the iris sphincter muscle causing miosis (C), or a decrease in heart rate (D), as these are more characteristic of sympathetic stimulation.
Question 2 of 5
Which of the following parts of the digestive tract most likely represents the main site of absorption of hydrochlorothiazide?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
Which of the following permeation processes mediated the man's intestinal absorption of ethanol after drinking alcoholic beverages?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
What percentage of valproic acid was most likely lipid soluble in the patient's duodenal lumen?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
A 59-year-old Japanese man with atrial fibrillation presented to his physician complaining of red urine. The man had been receiving a standard dose of warfarin, which is an anticoagulant drug biotransformed by CYP2C9 isozyme. Which of the following was the most likely cause of the patient's disorder?
Correct Answer: C
Rationale: The most likely cause of the patient's disorder is a genetic polymorphism of CYP2C9. Genetic variations in the CYP2C9 gene can affect the metabolism of warfarin, leading to either increased or decreased drug levels in the body. In this case, the patient's red urine could be a result of altered metabolism of warfarin due to genetic polymorphism in the CYP2C9 isozyme, which is responsible for metabolizing warfarin. This can result in either increased or decreased levels of the active form of warfarin in the body, potentially leading to adverse effects like red urine.