ATI RN
ATI Pharmacology Exam Practice Questions
Question 1 of 5
Which one of the following antipsychotics has been shown to be a partial agonist at the dopamine D2 receptor?
Correct Answer: A
Rationale: Aripiprazole, a third-generation antipsychotic, acts as a partial agonist at D2 receptors, stabilizing dopamine activity: it activates receptors in low-dopamine states (e.g., negative symptoms) and competes with excess dopamine (e.g., psychosis), reducing side effects like EPS. Clozapine, a second-generation drug, has weak D2 affinity, targeting 5HT2 and other receptors. Haloperidol, a first-generation antipsychotic, is a D2 antagonist. Risperidone and thioridazine block D2 fully, not partially. Aripiprazole's unique partial agonism, confirmed by pharmacological data, balances efficacy and tolerability, distinguishing it in schizophrenia treatment.
Question 2 of 5
A client calls the clinic and tells the nurse that she has missed taking several of her contraceptive pills during the current cycle. What is the best instruction for the nurse to give the client?
Correct Answer: D
Rationale: Missing several contraceptive pills compromises efficacy, requiring an alternative method for the cycle to prevent pregnancy. Testing assesses outcome, not prevention. Future methods don't address now. Fewer than three still risks failure. D ensures immediate protection, making it the best instruction.
Question 3 of 5
The nurse is caring for a client receiving tamoxifen (Nolvadex) for breast cancer. Which side effect should the nurse monitor for?
Correct Answer: A
Rationale: Tamoxifen, an estrogen receptor modulator, treats breast cancer but blocks estrogen in some tissues, causing hot flashes , a common menopausal-like effect. Monitoring this ensures client comfort and adherence, as it's frequent and distressing. Hair loss is more chemotherapy-related, not tamoxifen. Nausea and diarrhea occur less often and are less specific. Hot flashes align with tamoxifen's anti-estrogenic action, a key consideration in breast cancer management where long-term use is common. This focus aids in symptom management, distinguishing it from cytotoxic effects, making A the priority side effect to monitor.
Question 4 of 5
The following drugs exert their principal effects by enzyme inhibition:
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
The following are first-line drugs for hypertension in diabetics with proteinuria:
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.