Which one is true about the laboratory diagnosis of urinary tract infections

Correct Answer: D

Rationale: The correct answer is D because it encompasses the true statements regarding the laboratory diagnosis of urinary tract infections. A: Bacteriuria of less than 10^5 can be significant in treated patients due to the development of antibiotic resistance. B: Staphylococcus aureus, Salmonella typhi, and Mycobacterium tuberculosis may be significant regardless of quantity due to their pathogenic nature. C: Leukocyturia indicates inflammation, and even a lower number of leukocytes can be clinically significant. Therefore, option D covers all these aspects making it the correct choice.

Correct Answer: D

Rationale: The correct answer is D: Granulomatosis. The appearance of a 10 mm papule 48 hours after the Mantoux test indicates a delayed-type hypersensitivity reaction, which is characteristic of granulomatosis. This type of reaction involves activation of macrophages and T cells, leading to the formation of granulomas. Granulomas are organized collections of immune cells that wall off the antigen, in this case, the tuberculin antigen. A, B, and C are incorrect: A: Cellular cytotoxicity involves the destruction of target cells by immune cells such as cytotoxic T cells or natural killer cells. This mechanism is not associated with the delayed-type hypersensitivity reaction seen in granulomatosis. B: Anaphylaxis is a rapid and severe allergic reaction involving IgE-mediated release of histamine and other inflammatory mediators. This is not the mechanism underlying the delayed-type hypersensitivity reaction in the Mantoux test. C: Antibody-dependent cytotoxic

Correct Answer: A

Rationale: The correct answer is A: Neisser. Bacterial capsules can be stained using the Neisser staining method because it specifically targets the capsule, making it visible under a microscope. Neisser staining involves using a combination of acidic and basic dyes to highlight the capsule structure. This method helps differentiate the capsule from the bacterial cell, aiding in the identification and study of capsules. Choices B, C, and D are incorrect because Cleat and Müller staining methods are not commonly used for staining bacterial capsules, and "None of the above" is incorrect as Neisser staining is a valid method for capsule staining.

Correct Answer: D

Rationale: The correct answer is D. Staphylococcus aureus, Escherichia coli, and Clostridium difficile are all known for causing hospital-acquired infections. Staphylococcus aureus can cause skin infections and pneumonia. Escherichia coli can lead to urinary tract infections. Clostridium difficile is associated with gastrointestinal infections. Each of these bacteria has been linked to healthcare-associated infections due to their ability to spread in healthcare settings. Therefore, the correct answer is D. Choices A, B, and C are incorrect because each of these bacteria individually is known to cause hospital-acquired infections.

Correct Answer: C

Rationale: The correct answer is C (60 years) because as individuals age, their immune system weakens, making them more susceptible to infectious diseases. Around the age of 60, people are more likely to succumb to infections, leading to a higher mortality rate. Choices A, B, and D are incorrect because they are younger ages, and the likelihood of infectious diseases causing a significant proportion of deaths increases with age.

Correct Answer: A

Rationale: The correct answer is A: Streptococcus pneumoniae. The presence of Gram-positive cocci in pairs indicates a bacterial morphology consistent with Streptococcus pneumoniae, a common cause of pneumonia. This bacterium is known to appear in pairs or short chains on Gram stain. Staphylococcus aureus (B) typically presents as clusters of Gram-positive cocci, Neisseria meningitidis (C) is a Gram-negative diplococcus, and Klebsiella pneumoniae (D) is a Gram-negative rod, making them less likely causative agents in this scenario.

Correct Answer: D

Rationale: The correct answer is D: Paramyxoviridae. Mumps virus is a member of the Paramyxoviridae family, based on its characteristics such as structure, genome organization, and replication cycle. Paramyxoviruses are enveloped, non-segmented RNA viruses with a helical nucleocapsid. They replicate in the cytoplasm and bud from the host cell membrane. Coronaviridae (A) are a different family of viruses with distinct characteristics. Picornaviridae (B) and Orthomyxoviridae (C) are also different families with unique features that do not match those of the mumps virus.

Correct Answer: B

Rationale: The correct answer is B: Typhoid fever, Brucellosis. Both Typhoid fever and Brucellosis are bacterial infections that can lead to bacteremia, the presence of bacteria in the bloodstream. In Typhoid fever, the causative agent Salmonella typhi can enter the bloodstream, causing bacteremia. Similarly, Brucellosis, caused by Brucella species, can also result in bacteremia. Choice A is incorrect because bacteremia is not typically observed in Diphtheria. Choice C, Cholera, is caused by a toxin-producing bacterium and does not usually lead to bacteremia. Choice D, Dysentery, is a condition characterized by bloody diarrhea and is primarily caused by parasites or bacteria that typically do not lead to bacteremia.

Correct Answer: D

Rationale: The correct answer is D because it encompasses the true statements regarding the laboratory diagnosis of urinary tract infections. A: Bacteriuria of less than 10^5 can be significant in treated patients due to the development of antibiotic resistance. B: Staphylococcus aureus, Salmonella typhi, and Mycobacterium tuberculosis may be significant regardless of quantity due to their pathogenic nature. C: Leukocyturia indicates inflammation, and even a lower number of leukocytes can be clinically significant. Therefore, option D covers all these aspects making it the correct choice.