Which one IS NOT true for the urinary tract infections?

Correct Answer: A

Rationale: Step 1: Understand haematogenic spread means bacteria traveling through blood. Step 2: Urinary tract infections typically occur due to bacteria entering through urethra, not via blood. Step 3: Choice A states bacterial UTIs are usually after haematogenic spread, which is incorrect. Step 4: Therefore, Choice A is NOT true for UTIs. Summary: B, C, and D are incorrect as they align with typical characteristics of UTIs.

Correct Answer: A

Rationale: The correct answer is A: Staphylococcus epidermidis. The presence of Gram-positive cocci arranged in clusters, catalase-positive, and coagulase-negative characteristics are indicative of Staphylococcus species. Staphylococcus epidermidis is a common skin commensal that causes wound infections. Staphylococcus aureus is coagulase-positive and often causes more aggressive infections. Streptococcus pyogenes is catalase-negative and typically forms chains, not clusters. Enterococcus faecalis is catalase-negative and commonly found in the GI tract, not a common cause of wound infections.

Correct Answer: C

Rationale: The correct answer is C: Pili. Pili are bacterial structures involved in conjugation, which is the process of transferring genetic material between bacterial cells. Pili facilitate the physical contact between donor and recipient cells, allowing for the transfer of plasmids or other genetic material. Capsules (choice A) are involved in protection and adherence, not conjugation. Flagella (choice B) are responsible for bacterial motility. Fimbriae (choice D) are also involved in adherence but not in conjugation. Therefore, the correct answer is C as pili specifically play a crucial role in the process of conjugation.

Correct Answer: A

Rationale: The most likely diagnosis is Actinomycosis. This is because the patient's presentation of a painful swelling with a fistula containing white granules and yellow-green honeycomb-like tissue is classic for Actinomycosis. Actinomyces is a gram-positive anaerobic bacterium that forms sulfur granules in tissues. Tuberculosis (B) typically presents with caseating granulomas, not sulfur granules. Leprosy (C) presents with skin lesions and nerve damage, not characteristic of this case. Syphilis (D) usually presents with painless ulcers and rash, not the painful swelling and fistula seen in this patient.

Correct Answer: C

Rationale: The correct answer is C because Koch's postulate states that a microorganism must be isolated in pure culture, grown in a laboratory setting, and then inoculated into animals to reproduce the same disease seen in the original host. This step demonstrates a direct cause-and-effect relationship between the isolated microorganism and the disease. Choice A is incorrect because not all cases of a disease may have the same microorganism present. Choice B is incorrect as isolating the microorganism alone does not prove its pathogenicity. Choice D is incorrect as it does not address the need for experimental reproduction of the disease in a new host.

Correct Answer: D

Rationale: The correct answer is D (All of the above). All three bacteria (Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa) produce endotoxins that can lead to septic shock. Endotoxins are part of the outer membrane of Gram-negative bacteria and can trigger a strong immune response, leading to septic shock when released in large amounts. Escherichia coli and Salmonella enterica are common causes of bacterial septic shock, while Pseudomonas aeruginosa is known for its ability to produce endotoxins that contribute to severe infections and septic shock. Therefore, all three choices are correct in this context.

Correct Answer: D

Rationale: The correct answer is D because antibody diversity is generated by rearrangements of DNA encoding variable regions of heavy and light chains (choice A) and by the combination of different heavy and light chains that form the antigen binding site (choice B). Step 1: DNA rearrangements create different variable regions in heavy and light chains. Step 2: Combination of different heavy and light chains leads to unique antigen binding sites. Step 3: This diversity allows antibodies to bind to different epitopes on the same antigen. Step 4: Choice C is incorrect as antibodies do not physically change shape to bind different epitopes.

Correct Answer: D

Rationale: The correct answer is D: Neuraminidase inhibitors. Neuraminidase is an enzyme crucial for the release of new viral particles from infected cells during influenza infection. By inhibiting neuraminidase, the spread of the virus is limited. Protease inhibitors (choice A) are used to treat HIV, not influenza. Beta-lactamase inhibitors (choice B) are used in combination with beta-lactam antibiotics to increase their effectiveness against bacteria, not viruses. Reverse transcriptase inhibitors (choice C) are used to treat HIV by blocking the enzyme responsible for replicating the virus's genetic material, but they are not effective against influenza.

Correct Answer: A

Rationale: The correct answer is A: Overcrowding. Overcrowding can facilitate the spread of infectious diseases due to increased contact between individuals, making it easier for pathogens to transmit from one person to another. This is a risk factor on the part of the macroorganism as it directly impacts the likelihood of disease transmission. Environmental pollution (B) may impact overall health but is not a direct risk factor for infectious diseases. Physical fatigue (C) weakens the immune system but is not a direct facilitator of disease transmission. Ionizing radiation (D) can cause cellular damage but is not a typical risk factor for infectious diseases.