Which of these is an early symptom of rabies

Correct Answer: D

Rationale: The correct answer is D because all of the symptoms mentioned (short period of depression, nausea, restlessness) can be early signs of rabies. Rabies typically presents with a variety of non-specific symptoms in the early stages, including behavioral changes such as depression and restlessness, as well as gastrointestinal symptoms like nausea. Therefore, it is important to consider the combination of these symptoms collectively rather than individually when suspecting rabies. Choices A, B, and C alone may not definitively indicate rabies, but when seen together, they should raise suspicion and prompt further evaluation and testing for rabies.

Correct Answer: A

Rationale: The correct answer is A: Clostridium botulinum. This bacterium is responsible for causing botulism due to its production of botulinum toxin, which is one of the most potent neurotoxins known. Clostridium botulinum thrives in anaerobic conditions like improperly canned foods. Staphylococcus aureus (B), Bacillus anthracis (C), and Pseudomonas aeruginosa (D) do not produce the botulinum toxin and are not associated with botulism. Staphylococcus aureus is known for causing food poisoning, Bacillus anthracis for anthrax, and Pseudomonas aeruginosa for various infections, but not botulism.

Correct Answer: B

Rationale: The correct answer is B: Malaria. Fever developing 2 weeks post-blood transfusion is characteristic of malaria due to the incubation period of the parasite. Trypanosomiasis presents earlier, amebiasis usually causes GI symptoms, and toxoplasmosis typically manifests with flu-like symptoms. Malaria is the most likely cause based on the timing and clinical presentation.

Correct Answer: A

Rationale: The correct answer is A: The lysozyme hydrolyzes the glycoside bonds between the N-acetylmuramic acid and the N-acetylglucosamine in the peptidoglycan of the cell wall. This is because lysozyme is an enzyme that specifically targets the peptidoglycan layer of bacterial cell walls, breaking down the structure by cleaving the glycosidic bonds between these two specific sugar molecules. This action weakens the cell wall, leading to bacterial cell lysis. The other choices are incorrect because lysozyme does not target phosphate bonds in phospholipids (B), disulfide bonds in immunoglobulins (C), or hydrogen bonds in bacterial capsules (D).

Correct Answer: D

Rationale: The correct answer is D because all three choices, Clostridium botulinum, Morbillivirus morbillorum, and Clostridium tetani, can cause infections of the central nervous system (CNS). Clostridium botulinum can lead to botulism, which affects the nervous system. Morbillivirus morbillorum can cause measles, which can lead to viral encephalitis. Clostridium tetani can cause tetanus, which affects the CNS by producing neurotoxins. Therefore, all three choices are pathogens that can cause infections of the CNS.

Correct Answer: C

Rationale: The correct answer is C: crateriform. In a gelatin stab, a saucer-shaped liquefaction indicates a depression or crater-like shape. This term accurately describes the appearance of the liquefaction. A: napiform means turnip-shaped, which is not relevant to the shape in a gelatin stab. B: saccate means pouch-like, which does not match the saucer-shaped description. D: stratiform refers to something in layers, which is not applicable to the shape of the liquefaction. Therefore, C is the most appropriate term to describe the saucer-shaped liquefaction in a gelatin stab.

Correct Answer: D

Rationale: The correct answer is D because all of the symptoms mentioned (short period of depression, nausea, restlessness) can be early signs of rabies. Rabies typically presents with a variety of non-specific symptoms in the early stages, including behavioral changes such as depression and restlessness, as well as gastrointestinal symptoms like nausea. Therefore, it is important to consider the combination of these symptoms collectively rather than individually when suspecting rabies. Choices A, B, and C alone may not definitively indicate rabies, but when seen together, they should raise suspicion and prompt further evaluation and testing for rabies.

Correct Answer: A

Rationale: The correct answer is A: Pseudomonas aeruginosa. Pseudomonas aeruginosa is known for producing a blue-green pigment called pyocyanin, which is characteristic of its colonies. This bacterium is commonly associated with purulent infections, especially in immunocompromised patients. Proteus vulgaris (B) is not typically associated with blue-green pigment production. Bacillus subtilis (C) is not a common pathogen in wound infections. Klebsiella pneumoniae (D) does not produce blue-green pigment and is more commonly associated with respiratory infections. Therefore, based on the clinical presentation and pigment production, Pseudomonas aeruginosa is the most likely causative agent in this case.

Correct Answer: A

Rationale: The correct answer is A: Rifampicin. Rifampicin can cause red-orange discoloration of bodily fluids like urine due to its metabolism. This phenomenon is harmless but alarming to patients. Isoniazid (B) can cause peripheral neuropathy, Pyrazinamide (C) can cause hyperuricemia, and Ethambutol (D) can cause optic neuropathy.