Which of the following vitamins is given along with isoniazide in treatment of tuberculosis?

Correct Answer: C

Rationale: The correct answer is C: Pyridoxine. Isoniazid used in tuberculosis treatment can lead to pyridoxine deficiency, causing peripheral neuropathy. Therefore, supplementing with pyridoxine is essential. Nicotinic acid (A) is not directly related to isoniazid therapy. Riboflavin (B) deficiency is not a common issue with isoniazid. Ascorbic acid (D) does not play a role in preventing isoniazid-induced neuropathy.

Correct Answer: D

Rationale: Certainly! The correct answer is D: All of the above. 25-hydroxyvitamin D3 (calcifediol) can lead to hypercalcemia due to increased absorption of calcium, pruritus as a potential allergic reaction, and GI toxicity including symptoms like nausea, vomiting, and abdominal pain. Each option represents a possible side effect of calcifediol, making choice D the correct answer encompassing all potential adverse effects.

Correct Answer: D

Rationale: The correct answer is D: Hydrocortisone, as it is a glucocorticoid, not a mineralocorticoid. Mineralocorticoids regulate electrolyte and fluid balance, primarily aldosterone, deoxycorticosterone, and fludrocortisone. Hydrocortisone primarily functions as a glucocorticoid to regulate metabolism and immune response, not electrolyte balance.

Correct Answer: A

Rationale: The correct answer is A: Inhibition of bacterial cell division. Bacteriostatic effect refers to the ability to inhibit the growth and reproduction of bacteria without necessarily killing them. By inhibiting bacterial cell division, it prevents the bacteria from multiplying and causing further infection. This is different from choice B as it specifically targets cell division rather than just growth. Choice C is incorrect as it describes bactericidal effect, which involves destroying bacterial cells. Choice D is unrelated as bacterial L-forms are a specific type of bacterial cell variant, not related to bacteriostatic effect.

Correct Answer: D

Rationale: Resorptive sulfonamides are known to cause hematological adverse effects. Hemolytic anemia occurs due to the destruction of red blood cells, thrombocytopenia is a decrease in platelet count leading to bleeding disorders, and granulocytopenia is a reduction in granulocyte count affecting immunity. Therefore, all of the above choices (A, B, and C) are correct as resorptive sulfonamides can lead to hemolytic anemia, thrombocytopenia, and granulocytopenia. These adverse effects are well-documented in literature and clinical practice.