Which of the following statements is NOT true?

Correct Answer: B

Rationale: The correct answer is B because there are no reports of the Black Death dating back to 1000 B.C. The Black Death specifically refers to the pandemic outbreak of the bubonic plague in the 14th century. The first recorded pandemic of the Black Death occurred in the 14th century, not in 1000 B.C. The other choices are incorrect because A is true as the Black Death did devastate Europe in the 14th century, C is true as plague is still present in some countries, and D is true as plague can be treated with antibiotics if caught early.

Correct Answer: D

Rationale: The correct answer is D because NLRP3 is not found in complex with pro-caspase 1 in resting, non-activated cells. Inflammasome formation requires assembly of NLRP3 with ASC and pro-caspase 1. Choices A, B, and C are correct statements because activation of receptors like TLRs can trigger inflammasome formation, extracellular ATP can induce inflammasome formation, and environmental triggers such as asbestos can also lead to inflammasome activation.

Correct Answer: C

Rationale: The correct answer is C: Bone marrow. B cells undergo maturation in the bone marrow, where they develop from hematopoietic stem cells. This is where they acquire their antigen receptors and differentiate into mature B cells. Lymph nodes (A) are primarily responsible for filtering lymph and containing immune cells. The spleen (B) is involved in filtering blood and storing immune cells. The thymus (D) is where T cells mature, not B cells. Therefore, the correct site for B cell maturation is the bone marrow.

Correct Answer: D

Rationale: The correct answer is D. The inflammatory response can be triggered by microbial-infected cells releasing cytokines, internal tissue injury leading to the release of inflammatory mediators, and the migration of erythrocytes from the spleen in response to inflammation. Therefore, all of the choices - A, B, and C - are correct in contributing to the inflammatory response. Each option plays a role in the complex cascade of events that lead to inflammation.

Correct Answer: D

Rationale: Step-by-step rationale: 1. The Peripheral Nervous System (PNS) includes nerves and ganglia, making choice B correct. 2. PNS is located outside the Central Nervous System (CNS), supporting choice A. 3. Since both A and B are accurate statements, the correct answer is D. Summary: - Choice A is correct because the PNS is located outside the CNS. - Choice B is correct as the PNS includes nerves and ganglia. - Choice C is incorrect as it refers to the CNS (Brain & Spinal cord).