Which of the following statements about estrogens are True:

Correct Answer: D

Rationale: Step 1: Estrogens are required for normal sexual maturation and growth of the female. This is true as estrogens play a key role in the development of secondary sexual characteristics and growth. Step 2: Estrogens decrease the rate of resorption of bone. This is true as estrogens help maintain bone density by inhibiting bone breakdown. Step 3: Estrogens enhance the coagulability of blood. This is true as estrogens can increase clotting factors leading to enhanced blood coagulability. Step 4: Combining the above points, it is evident that all the statements are true, making choice D the correct answer. Other choices are incorrect as they do not align with the established functions of estrogens.

Correct Answer: B

Rationale: The class of OKT-3 is monoclonal antibodies. OKT-3 is a specific monoclonal antibody used for immunosuppression in organ transplant recipients. Monoclonal antibodies are designed to target specific antigens or proteins in the body. Other choices are incorrect as interferons are cytokines, immunoglobulins are antibodies produced by plasma cells, and immunosuppressive agents are a broad category that includes various drugs targeting the immune system.

Correct Answer: C

Rationale: Step-by-step rationale: 1. Polar bear liver contains high levels of Vitamin A. 2. Excessive Vitamin A intake can lead to acute poisoning. 3. Symptoms of Vitamin A poisoning include nausea, vomiting, dizziness, and even death. 4. Thus, ingestion of polar bear liver can cause acute poisoning due to Vitamin A overload. Summary: A: Vitamin D - Incorrect. Polar bear liver does not contain toxic levels of Vitamin D. B: Vitamin E - Incorrect. Vitamin E toxicity is rare and not associated with polar bear liver ingestion. C: Vitamin A - Correct. Polar bear liver is high in Vitamin A, leading to acute poisoning if consumed in excess. D: Vitamin C - Incorrect. Vitamin C toxicity is unlikely from consuming polar bear liver.

Correct Answer: A

Rationale: The correct answer is A: TRUE. Gemfibrozil (Lopid) is known to be more effective at increasing HDL cholesterol levels compared to clofibrate (Atromid-S). This is supported by clinical studies showing a greater impact on HDL concentrations with gemfibrozil. Choice B is incorrect as it contradicts the established evidence. Choices C and D are also incorrect as they do not accurately reflect the comparative efficacy between Gemfibrozil and clofibrate in increasing HDL cholesterol levels.

Correct Answer: C

Rationale: Rationale: 1. Both Doxercalciferol (Hectoral) and Paricalcitol (Zemplar) are synthetic analogs of 1,25-dihydroxyvitamin D3. 2. Doxercalciferol is converted to calcitriol in the body. 3. Paricalcitol is a selective vitamin D receptor activator. Summary: A: Doxercalciferol is correct as it is a synthetic analog of calcitriol. B: Paricalcitol is correct as it is also a synthetic analog of calcitriol. C: Correct as both A and B are true. D: Incorrect as both A and B are commercially available analogs of calcitriol.