ATI RN
The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs Questions
Question 1 of 5
Which of the following statements about estrogens are True:
Correct Answer: D
Rationale: The correct answer is D: All of the above. Rationale: A: True. Estradiol binds strongly to α2-globulin and albumin with lower affinity compared to estrone and estriol. B: True. Estradiol is metabolized in the liver and other tissues to estrone, estriol, and their derivatives before being excreted in bile. C: True. Estrone and estriol have lower affinity for estrogen receptors compared to estradiol but still exhibit estrogenic effects. Therefore, all statements are accurate, making option D the correct answer. Other choices are incorrect as they do not accurately depict the properties and metabolism of estrogens.
Question 2 of 5
The indication for interferon gamma administration is:
Correct Answer: C
Rationale: Interferon gamma is indicated for Chronic Granulomatous Disease (CGD) due to its role in enhancing the immune response against intracellular pathogens. CGD is a genetic disorder where phagocytes are unable to produce reactive oxygen species, leading to recurrent infections. Interferon gamma helps activate macrophages to improve host defense against pathogens in CGD patients. Incorrect choices: A: Idiopathic nephrotic syndrome - Interferon gamma is not indicated for this condition as it is primarily used for immune modulation, not for kidney-related issues. B: Hepatitis C virus infection - While interferon alpha is used for hepatitis C, interferon gamma is not the primary treatment for this viral infection. D: Hairy cell leukemia - Interferon alpha is the preferred treatment for hairy cell leukemia, not interferon gamma.
Question 3 of 5
Which of the following antivitamins prevent a vitamin A from exerting its typical metabolic effects?
Correct Answer: A
Rationale: The correct answer is A: Lipooxidase. Antivitamins are substances that interfere with the absorption, metabolism, or utilization of vitamins. In this case, antivitamin A would prevent vitamin A from exerting its typical effects. Lipooxidase is an antivitamin that inhibits the action of vitamin A by interfering with its metabolic pathways. Summary: - Oral contraceptives do not prevent vitamin A from exerting its effects. - Antibiotics do not prevent vitamin A from exerting its effects. - Therefore, the correct answer is A: Lipooxidase.
Question 4 of 5
When used alone, the bile acid-binding resins are contraindicated in patients with hypertriglyceridemia. This consideration is:
Correct Answer: A
Rationale: The correct answer is A: TRUE. Bile acid-binding resins can worsen hypertriglyceridemia by increasing triglyceride levels. This is due to the compensatory increase in hepatic triglyceride synthesis. Choice B is incorrect because it contradicts this established fact. Choice C is incorrect as it implies all options are true, which is not the case. Choice D is incorrect as it suggests that none of the options are true, which is also not accurate.
Question 5 of 5
Route of administration of dihydrotachysterol is:
Correct Answer: C
Rationale: The correct answer is C: Oral. Dihydrotachysterol is a form of vitamin D used to treat hypoparathyroidism. The oral route is chosen for its optimal absorption in the gastrointestinal tract. Intravenous (A) and subcutaneous (B) routes are not commonly used for dihydrotachysterol administration due to potential adverse effects and lack of significant benefits. Intranasal (D) administration is not suitable for dihydrotachysterol as it is not designed to be absorbed through the nasal mucosa.