ATI RN
ATI Hematologic System Test Questions
Question 1 of 5
Which of the following requires IL-2 and IL-4 in the conversion of unilineage progenitor cell into mature circulating cell?
Correct Answer: D
Rationale: The correct answer is D: B lymphocyte. IL-2 and IL-4 are crucial for the differentiation of B lymphocytes from unilineage progenitor cells. IL-2 supports proliferation and survival of B cells, while IL-4 promotes their differentiation into mature circulating cells. Neutrophils, eosinophils, and basophils develop independently of IL-2 and IL-4. Neutrophils mainly require granulocyte colony-stimulating factor (G-CSF), eosinophils require IL-5, and basophils are influenced by IL-3 and IL-5. Therefore, the correct answer is D as B lymphocytes specifically rely on IL-2 and IL-4 for their maturation.
Question 2 of 5
The typical Reed-Sternberg cells are either infrequent or absent. Instead, lymphocytic and histiocytic cells or 'popcorn cells' are seen within a background of inflammatory cells, which are predominantly benign lymphocytes. Which type of Hodgkin's lymphoma best suit the description?
Correct Answer: D
Rationale: The correct answer is D: Lymphocyte predominance. In this type of Hodgkin's lymphoma, the typical Reed-Sternberg cells are absent or rare. Instead, popcorn cells (lymphocytic and histiocytic cells) are seen among benign lymphocytes. This is characteristic of lymphocyte predominance subtype. A: Nodular sclerosis - characterized by lacunar Reed-Sternberg cells in a background of collagen bands. B: Mixed cellularity - characterized by numerous Reed-Sternberg cells, eosinophils, plasma cells, and histiocytes in a background of mixed inflammatory cells. C: Lymphocyte depleted - characterized by few Reed-Sternberg cells in a background of fibrosis and few inflammatory cells. Therefore, based on the description provided, choice D is the most appropriate answer.
Question 3 of 5
Mr XY was found to be anemic. During history taking, he informed his doctor that he was a strict vegetarian who did not consume any meat, fish or milk products.
Correct Answer: B
Rationale: Correct Answer: B (Vitamin B12 deficiency) Rationale: 1. Mr. XY is a strict vegetarian, avoiding meat, fish, and milk products. 2. Vitamin B12 is mainly found in animal products, crucial for red blood cell production. 3. Vegetarians at risk of B12 deficiency due to limited dietary sources. 4. Anemia can result from B12 deficiency, leading to decreased red blood cell production. Summary: A: Iron deficiency - Possible but less likely since vegetarian diets can still provide iron. C: Defects in erythropoietin production - Unrelated to diet, more related to kidney function. D: Calcium-deficiency - Not directly related to anemia; more associated with bone health.
Question 4 of 5
Bone marrow responds to iron therapy by increasing erythropoietic activity. Which of the following in bone marrow would most likely indicate erythropoiesis?
Correct Answer: B
Rationale: The correct answer is B: Reticulocytes. Reticulocytes are immature red blood cells released by the bone marrow into the bloodstream in response to increased erythropoietic activity. They indicate ongoing erythropoiesis as they mature into fully functional red blood cells. Myelocytes (A) are immature granulocytic precursors, not involved in erythropoiesis. Ring sideroblasts (C) are seen in conditions like sideroblastic anemia and indicate abnormal iron metabolism. Target cells (D) are red blood cells with a central bull's eye appearance and are associated with conditions like liver disease and thalassemias, not specifically erythropoiesis.
Question 5 of 5
Dohle bodies are patches of dilated endoplasmic reticulum that appear as cerulean blue cytoplasmic puddles. These findings are mostly seen in
Correct Answer: D
Rationale: The correct answer is D: Infectious mononucleosis. Dohle bodies are seen in infectious mononucleosis due to the accumulation of rough endoplasmic reticulum in neutrophils. This is a result of the viral infection causing stress on the neutrophils. In chronic myeloid leukemia (A), leukemoid reaction (B), and Chediak-Higashi syndrome (C), Dohle bodies are not typically observed. In chronic myeloid leukemia, the characteristic finding is the Philadelphia chromosome. Leukemoid reaction is a reactive increase in white blood cells due to infection or inflammation. Chediak-Higashi syndrome is a rare autosomal recessive disorder characterized by defective phagolysosome formation.