ATI RN
ATI Hematologic System Test Questions
Question 1 of 5
Which of the following requires IL-2 and IL-4 in the conversion of unilineage progenitor cell into mature circulating cell?
Correct Answer: D
Rationale: The correct answer is D: B lymphocyte. IL-2 and IL-4 are essential for the differentiation of B lymphocytes from unilineage progenitor cells into mature circulating cells. IL-2 is crucial for B cell proliferation and survival, while IL-4 is required for B cell activation and class switching. Neutrophils do not require IL-2 and IL-4 for differentiation. Eosinophils are primarily influenced by IL-5. Basophils are influenced by IL-3 and IL-5. Therefore, B lymphocytes are the only cell type among the choices that specifically requires IL-2 and IL-4 for their maturation.
Question 2 of 5
The typical Reed-Sternberg cells are either infrequent or absent. Instead, lymphocytic and histiocytic cells or 'popcorn cells' are seen within a background of inflammatory cells, which are predominantly benign lymphocytes. Which type of Hodgkin's lymphoma best suit the description?
Correct Answer: D
Rationale: Rationale for Choice D (Lymphocyte predominance): 1. Reed-Sternberg cells are infrequent or absent in lymphocyte predominance Hodgkin's lymphoma. 2. 'Popcorn cells' are seen in lymphocyte predominance Hodgkin's lymphoma. 3. Predominance of benign lymphocytes in the background is characteristic of lymphocyte predominance Hodgkin's lymphoma. Summary of other choices: A: Nodular sclerosis - Characterized by collagen bands dividing lymph node into nodules, not 'popcorn cells'. B: Mixed cellularity - Reed-Sternberg cells present, not 'popcorn cells'. C: Lymphocyte depleted - Few to no lymphocytes seen, not benign lymphocytes as described in the question.
Question 3 of 5
Mr XY was found to be anemic. During history taking, he informed his doctor that he was a strict vegetarian who did not consume any meat, fish or milk products.
Correct Answer: B
Rationale: The correct answer is B: Vitamin B12 deficiency. As a strict vegetarian who does not consume any meat, fish, or milk products, Mr XY is at risk for Vitamin B12 deficiency. Vitamin B12 is primarily found in animal products and is essential for red blood cell production. Anemia can result from Vitamin B12 deficiency, leading to symptoms such as fatigue and weakness. Iron deficiency (A) is also common in vegetarians, but in this case, the focus is on Vitamin B12 due to the exclusion of all animal products. Defects in erythropoietin production (C) are not related to Mr XY's dietary choices. Calcium-deficiency (D) is not directly related to anemia in this scenario.
Question 4 of 5
Bone marrow responds to iron therapy by increasing erythropoietic activity. Which of the following in bone marrow would most likely indicate erythropoiesis?
Correct Answer: B
Rationale: Rationale: 1. Bone marrow increases erythropoiesis in response to iron therapy. 2. Reticulocytes are immature red blood cells derived from erythroblasts, indicating active erythropoiesis. 3. Myelocytes are precursors of granulocytes, not involved in erythropoiesis. 4. Ring sideroblasts are abnormal erythroblasts with iron granules, not indicative of active erythropoiesis. 5. Target cells are red blood cells with central "target-like" appearance due to excess membrane, not directly related to erythropoiesis.
Question 5 of 5
Dohle bodies are patches of dilated endoplasmic reticulum that appear as cerulean blue cytoplasmic puddles. These findings are mostly seen in
Correct Answer: D
Rationale: Step-by-step rationale for why choice D (Infectious mononucleosis) is correct: 1. Infectious mononucleosis is caused by the Epstein-Barr virus. 2. Dohle bodies are seen in the peripheral blood of patients with infectious mononucleosis. 3. These bodies represent aggregates of rough endoplasmic reticulum in neutrophils. 4. The appearance of Dohle bodies is attributed to the viral infection in infectious mononucleosis. Summary: A: Chronic myeloid leukemia - Dohle bodies are not typically seen in this condition. B: Leukemoid reaction - Dohle bodies are not specific to a leukemoid reaction. C: Chediak-Higashi syndrome - This syndrome is characterized by giant granules in neutrophils, not Dohle bodies.