ATI RN
ATI Pharmacology Assessment 2 Questions
Question 1 of 5
Which of the following refers to the metabolism of the drug en route from the GUT lumen to the systemic circulation.
Correct Answer: B
Rationale: The first pass effect refers to the metabolism of a drug occurring as it passes from the gastrointestinal tract (GUT lumen) to the liver, before reaching the systemic circulation. This process can significantly reduce the amount of active drug that enters systemic circulation, impacting the drug's overall effectiveness. The first pass effect is an important consideration in pharmacokinetics as it affects the bioavailability of a drug and influences dosing regimens. Options A, C, D, and E do not specifically pertain to the metabolism of a drug en route from the GUT lumen to the systemic circulation as described in the question.
Question 2 of 5
The nurse assesses the patient receiving phentolamine (Regitine) and suspects what finding is an adverse effect of the medication?
Correct Answer: C
Rationale: Patients receiving phentolamine often experience extensions of the therapeutic effects, including hypotension, orthostatic hypotension, angina, myocardial infarction, cerebrovascular accident, flushing, tachycardia, and arrhythmia all of which are related to vasodilation and decreased blood pressure. Headache, weakness, and dizziness often occur in response to hypotension. Nausea, vomiting, and diarrhea may also occur. Hypertension, wheezing, and depressed respiration would not be associated with phentolamine. The nurse should monitor for adverse effects and intervene as needed.
Question 3 of 5
The nurse will be administering an antitussive medication containing codeine to a patient. What is the priority assessment?
Correct Answer: C
Rationale: Codeine, an opioid antitussive, can cause respiratory depression as a side effect. The nurse must assess the patient’s respiratory rate before administration to ensure it is within a safe range (typically >12 breaths per minute). While lung sounds (B) and sputum consistency (D) are important, they are not the priority when administering a medication that can suppress respiration. Pulse oximetry (A) is useful but secondary to direct respiratory rate assessment.
Question 4 of 5
Colchicine is prescribed for a client with gout. The nurse reviews the client’s record, knowing that this medication would be used in caution in which of the following medical conditions?
Correct Answer: B
Rationale: Colchicine should be used with caution in patients with aplastic anemia or other blood dyscrasias, as it can exacerbate bone marrow suppression. While colchicine is used to treat conditions like Behcet disease and familial Mediterranean fever, it is not contraindicated in these conditions. Amyloidosis is not a primary concern with colchicine use. Monitoring blood counts is essential in patients with pre-existing hematologic conditions.
Question 5 of 5
The nurse is giving instructions to a client receiving phenytoin (Dilantin). The nurse concludes that the client has a sufficient knowledge if the client states that:
Correct Answer: D
Rationale: Monitoring serum phenytoin levels is essential to ensure therapeutic efficacy and avoid toxicity. Wearing a medical alert tag is recommended for clients on phenytoin. Alcohol should be avoided, and taking the medication with milk can interfere with absorption. Therefore, the correct statement indicating sufficient knowledge is about monitoring serum levels.