Which of the following organism is notorious for developing antimicrobial resistance rapidly?:

Correct Answer: D

Rationale: The correct answer is D: Escherichia coli. E. coli is notorious for developing antimicrobial resistance rapidly due to its ability to acquire resistance genes through plasmid exchange and mutation. This bacterium is commonly found in the gut of humans and animals, leading to frequent exposure to antibiotics. On the other hand, choices A, B, and C are less likely to develop resistance as rapidly as E. coli due to their lower frequency of exposure to antibiotics and differences in genetic makeup. Streptococcus pyogenes is susceptible to penicillin, Meningococcus has shown susceptibility to several antibiotics, and Treponema pallidum has limited exposure to antibiotics due to its unique nature as the causative agent of syphilis.

Correct Answer: C

Rationale: The correct answer is C: Hydrochlorothiazide. Hydrochlorothiazide is a thiazide diuretic that works by reducing calcium excretion and increasing uric acid levels, which can lead to gout attacks in susceptible individuals. Furosemide (choice A) is a loop diuretic that does not increase uric acid levels. Spironolactone (choice B) is a potassium-sparing diuretic and does not affect calcium or uric acid levels significantly. Triamterene (choice D) is also a potassium-sparing diuretic and does not impact calcium or uric acid levels in the same way as hydrochlorothiazide.

Correct Answer: D

Rationale: The correct answer is D: Conivaptan. Conivaptan is a non-peptide competitive antagonist of ADH, indicated for managing SIADH by blocking ADH's water-sparing effects in the collecting ducts. Mannitol (A) is an osmotic diuretic used for reducing intracranial pressure, not specifically for SIADH. Bumetanide (B) is a loop diuretic used for conditions like heart failure and edema. Spironolactone (C) is a potassium-sparing diuretic used for conditions like hypertension and heart failure, not specifically for SIADH.

Correct Answer: C

Rationale: Acetazolamide is a carbonic anhydrase inhibitor that reduces intraocular pressure by decreasing aqueous humor production, making it effective in treating glaucoma. It is not commonly used as a diuretic due to its short duration of action and side effects. Therefore, choice C is correct. Choices A, B, and D are incorrect as acetazolamide is not indicated for liver cirrhosis, CHF, or kidney failure. Liver cirrhosis typically requires diuretics to manage ascites, CHF is managed with loop diuretics, and kidney failure may require different types of diuretics based on the underlying cause.

Correct Answer: C

Rationale: The correct answer is C: Encourage fluid intake of 3000 mL/day. This is important post-nephrolithotomy to prevent urinary stasis and aid in flushing out potential stone fragments. Adequate hydration also helps in preventing urinary tract infections. Administering IV fluids and blood transfusions (A) may be necessary in certain cases, but not specifically indicated for this scenario. Administering narcotic analgesics (B) may be required for pain management, but it does not address the underlying issue of preventing complications. Suggesting herbs or spices (D) is unrelated and may not be recommended due to potential interactions with medications.