Which of the following NSAIDs is a fenamate derivative?

Correct Answer: C

Rationale: The correct answer is C: Meclofenamic acid. Fenamate derivatives are a specific class of NSAIDs that have a fenamic acid structure. Meclofenamic acid is a fenamate derivative as it contains the fenamic acid structure, making it the correct choice. A: Phenylbutazone is not a fenamate derivative, it belongs to the pyrazolidinedione class. B: Indomethacin is not a fenamate derivative, it belongs to the indoleacetic acid class. D: Diclofenac is not a fenamate derivative, it belongs to the acetic acid class.

Correct Answer: C

Rationale: The correct answer is C: Pyridoxine. Isoniazid used in tuberculosis treatment can lead to pyridoxine deficiency, causing peripheral neuropathy. Therefore, supplementing with pyridoxine is essential. Nicotinic acid (A) is not directly related to isoniazid therapy. Riboflavin (B) deficiency is not a common issue with isoniazid. Ascorbic acid (D) does not play a role in preventing isoniazid-induced neuropathy.

Correct Answer: A

Rationale: The correct answer is A: TRUE. Lovastatin combined with a bile-acid binding resin has been shown to cause regression of coronary lesions in about one third of treated patients. This is supported by clinical studies and research, demonstrating the effectiveness of this combination therapy in improving coronary health. The other choices are incorrect because they do not accurately reflect the evidence and outcomes of this specific treatment approach. Choice B (FALSE) is incorrect because there is evidence to support the regression of coronary lesions with this treatment. Choice C (All) is incorrect because not all patients treated with this combination therapy experience regression of coronary lesions. Choice D (None) is incorrect as there is a significant proportion of patients who do benefit from this treatment in terms of lesion regression.

Correct Answer: D

Rationale: Certainly! The correct answer is D: All of the above. 25-hydroxyvitamin D3 (calcifediol) can lead to hypercalcemia due to increased absorption of calcium, pruritus as a potential allergic reaction, and GI toxicity including symptoms like nausea, vomiting, and abdominal pain. Each option represents a possible side effect of calcifediol, making choice D the correct answer encompassing all potential adverse effects.

Correct Answer: D

Rationale: The correct answer is D: Hydrocortisone, as it is a glucocorticoid, not a mineralocorticoid. Mineralocorticoids regulate electrolyte and fluid balance, primarily aldosterone, deoxycorticosterone, and fludrocortisone. Hydrocortisone primarily functions as a glucocorticoid to regulate metabolism and immune response, not electrolyte balance.