Which of the following nitrates and nitrite drugs are long-acting?

Correct Answer: D

Rationale: The correct answer is D: Sustac. Sustac is a long-acting nitrate drug that provides sustained release of nitroglycerin, leading to prolonged vasodilation effects. This is achieved through its formulation that allows for controlled and gradual release of the medication over an extended period of time. In contrast, options A, B, and C are short-acting nitrate drugs that are rapidly absorbed and have a shorter duration of action, making them unsuitable for long-term management of conditions requiring sustained vasodilation.

Correct Answer: C

Rationale: The correct answer is C: Triiodothyronine. The thyroid gland produces triiodothyronine (T3) along with its precursor hormone, thyroxine (T4), which are essential for regulating metabolism in the body. T3 is the active form of thyroid hormone that influences various physiological processes. Thyroid-stimulating hormone (TSH) is produced by the pituitary gland to stimulate the thyroid gland to produce T3 and T4, making choice A incorrect. Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus to stimulate the pituitary gland to produce TSH, making choice B incorrect. Thyroglobulin is a protein synthesized by the thyroid gland to store thyroid hormones, not a hormone itself, making choice D incorrect.

Correct Answer: D

Rationale: Progesterone is a hormone essential for pregnancy and menstrual cycle regulation. It is primarily secreted by the corpus luteum after ovulation. Ovarian follicles also produce progesterone during the menstrual cycle. Additionally, granulosa and theca cells in the ovaries contribute to progesterone production. Therefore, the correct answer is D, "All of the above," as all three options play a role in progesterone secretion. Choices A, B, and C individually are incorrect as they only represent specific sources of progesterone production.

Correct Answer: A

Rationale: Step 1: Thromboxane A2 (TXA2) is a potent vasoconstrictor and platelet aggregator. Step 2: Sulotroban is a specific TXA2 receptor antagonist, blocking its effects. Step 3: Zileuton inhibits 5-lipoxygenase, not directly related to TXA2 receptors. Step 4: Zafirleukast is a leukotriene receptor antagonist, not targeting TXA2 receptors. Step 5: Diclofenac is a non-selective NSAID, not a TXA2 receptor antagonist. Summary: Sulotroban is the correct choice as it directly blocks TXA2 receptors, while the other options target different pathways.

Correct Answer: C

Rationale: Interferon alpha is indicated in Kaposi's sarcoma due to its antiviral and anti-tumor properties. It helps in controlling the progression of the disease caused by human herpesvirus 8. Other options (A) Rh sensitization is managed by Rh immunoglobulin, (B) Rheumatoid arthritis is treated with disease-modifying anti-rheumatic drugs, and (D) Chronic granulomatous disease is managed with antibiotics and interferon-gamma.