Which of the following molecular actions most likely mediated the therapeutic effect of acetazolamide in this patient?

Correct Answer: A

Rationale: The correct answer is A: Inhibition of carbonic acid dehydration in the tubular lumen. Acetazolamide is a carbonic anhydrase inhibitor that works in the proximal convoluted tubule of the kidney to reduce bicarbonate reabsorption. By inhibiting carbonic anhydrase, it prevents the conversion of carbonic acid to bicarbonate and H+, leading to increased excretion of bicarbonate in the urine. This results in a systemic metabolic acidosis and a diuretic effect. Choices B, C, and D are incorrect because acetazolamide does not directly stimulate bicarbonate reabsorption in the proximal tubule, inhibit Na+ reabsorption in the early distal tubule, or stimulate H+ reabsorption in the proximal tubule. The primary mechanism of action of acetazolamide is through carbonic anhydrase inhibition, leading to its therapeutic effects.

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.