ATI RN
Central Nervous System Stimulants and Related Drugs NCLEX Style Questions Questions
Question 1 of 5
Which of the following molecular actions in the enteric nervous system most likely mediated the adverse effect of the drug in the 54-year-old woman?
Correct Answer: B
Rationale: The drug causing diarrhea in the woman is most likely paroxetine, which increases serotonergic activity in the enteric nervous system, leading to the adverse effect of diarrhea.
Question 2 of 5
Which of the following opiate receptors is paired correctly with a physiological or psychological action?
Correct Answer: C
Rationale: Mu receptors (choice C) mediate respiratory depression, a key morphine effect. Mu doesn't cause dysphoria (choice A), kappa causes dysphoria, not euphoria (choice B), and delta (choice D) isn't primarily dysphoric. This correct pairing reflects opioid pharmacology.
Question 3 of 5
A first-year surgery intern has rotated on numerous surgical services. He has gotten quite used to ordering morphine for pain control. However, which of the following is an absolute contraindication to opioid use?
Correct Answer: A
Rationale: Closed head injury (choice A) contraindicates morphine due to respiratory depression and ICP elevation, masking neurological signs. MI (choice B), pulmonary edema (choice C), and diarrhea (choice D) benefit from morphine. This exception ensures safety.
Question 4 of 5
Which of the following opioids would be contraindicated in this patient?
Correct Answer: A
Rationale: In a patient with acute myocardial infarction, morphine would be contraindicated due to its potential to cause hypotension and respiratory depression, which can exacerbate the patient's condition.
Question 5 of 5
A 72-year-old man is brought to his physician by his son. The son complains that this patient has been becoming forgetful, confused, moody, and aggressive over the past few months. One drug that may be used to treat this patient's symptoms is donepezil. Which of the following describes an effect of donepezil?
Correct Answer: D
Rationale: Donepezil, a cholinesterase inhibitor, increases synaptic acetylcholine levels by preventing its breakdown, improving cognitive function in Alzheimer's disease.