ATI RN
Pediatric Immune Disorder Test Questions Questions
Question 1 of 5
Which of the following MHC class II genes has the least alleles?
Correct Answer: D
Rationale: DRα has the fewest alleles among MHC class II genes.
Question 2 of 5
The T cell-APC interaction is MHC -restricted, and the T cell-target cell interaction is MHC -restricted.
Correct Answer: B
Rationale: CD4+ T cells interact with MHC class II on APCs; CD8+ T cells interact with MHC class I on target cells.
Question 3 of 5
Bacteria such as Mycobacterium tuberculosis have acquired the capacity to inhibit phagosome-lysosome fusion. What is a consequence of this?
Correct Answer: A
Rationale: Inhibiting phagosome-lysosome fusion reduces peptide generation for MHC Class II presentation, lowering surface expression.
Question 4 of 5
Protein tyrosine kinases (PTKs) play an important role in lymphocyte function and activation. A mutation in the genes encoding the enzyme ZAP-70 would lead to which of the following?
Correct Answer: C
Rationale: ZAP-70 mutations impair T cell signaling, leading to SCID due to defective T cell development.
Question 5 of 5
Critical in antigen-capture and uptake in peripheral tissues
Correct Answer: D
Rationale: Dendritic cells capture and present antigens in tissues.