Which of the following isotypes of antibodies activate the complement cascade if bound to antigen?

Questions 60

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Pediatric Immunization NCLEX Questions Quizlet Questions

Question 1 of 5

Which of the following isotypes of antibodies activate the complement cascade if bound to antigen?

Correct Answer: D

Rationale: IgM and IgG effectively activate the complement cascade via the classical pathway when bound to antigens.

Question 2 of 5

Matching: Complement deficiency - Nonpitting edema

Correct Answer: D

Rationale: C1 inhibitor deficiency causes hereditary angioedema, characterized by nonpitting edema due to unregulated bradykinin production. Other complement deficiencies do not typically present with this feature.

Question 3 of 5

Matching: Immunodeficiency - Elevated IgE levels and eosinophilia

Correct Answer: D

Rationale: Hyper-IgE syndrome is defined by elevated IgE and eosinophilia, alongside recurrent infections and skin findings.

Question 4 of 5

In addition to recurrent staphylococcal abscesses and elevated serum IgE, the clinical manifestations of hyperimmunoglobulinemia E (hyper-IgE) syndrome frequently include which of the following?

Correct Answer: B

Rationale: Hyper-IgE syndrome commonly includes pneumatoceles (lung cysts) from recurrent pneumonias, alongside staphylococcal abscesses and high IgE.

Question 5 of 5

Long-term treatment of the disease described in Question 27 is best accomplished with

Correct Answer: D

Rationale: Granulocyte colony-stimulating factor (G-CSF) is the mainstay long-term treatment for Kostmann disease, boosting neutrophil production.

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