ATI RN
Good Questions About the Immune System Questions
Question 1 of 5
Which of the following is true about MHC II molecules?
Correct Answer: C
Rationale: MHC II binds longer peptides due to open ends ; HLA-D regions encode them , they're stable , and only on APCs .
Question 2 of 5
How are B cells tolerized in the bone marrow?
Correct Answer: B
Rationale: B cells edit receptors to avoid self-reactivity ; hypermutation enhances affinity, selection (C, D) is T-cell-specific.
Question 3 of 5
The most numerous and main cell in the inflammatory response is the
Correct Answer: B
Rationale: Neutrophils are the most abundant in acute inflammation; macrophages , monocytes , and basophils are less numerous.
Question 4 of 5
Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because:
Correct Answer: A
Rationale: Alternative/lectin pathways use innate recognition molecules ; MAC , inflammation , and phagocytosis are outcomes, not the innate basis.
Question 5 of 5
Individuals or mice with defects in the biochemical pathways needed for loading peptides onto MHC molecules show greatly increased susceptibility to virus infections. Experiments examining the MHC molecules present on the surface of host cells in these individuals would show:
Correct Answer: B
Rationale: Peptide loading defects (e.g., TAP) reduce MHC surface expression ; empty MHC or self-peptides are unstable.