ATI RN
Chemotherapy drugs Questions
Question 1 of 5
Which of the following is the best drug for biliary infection?
Correct Answer: C
Rationale: Cefoperazone is excreted in bile, making it ideal for biliary infections (e.g., cholangitis), unlike cefazolin, ampicillin, or gentamicin.
Question 2 of 5
A patient on warfarin therapy developed a chest infection for which he took antibacterial therapy. He suffered from bleeding. The antimicrobial taken most probably was:
Correct Answer: A
Rationale: Co-trimoxazole inhibits warfarin metabolism (CYP2C9), increasing INR and bleeding risk, unlike aztreonam, rifampicin (inducer), or gentamicin.
Question 3 of 5
In the previous case, this adverse effect can be avoided by:
Correct Answer: B
Rationale: Pretreating with antihistamines reduces vancomycin-induced histamine release, preventing flushing.
Question 4 of 5
A patient with a Pseudomonas aeruginosa infection is receiving IV gentamycin, but the clinical response is not satisfactory. If penicillin is administered in a separate IV line to avoid physical interaction, which of the following will occur?
Correct Answer: C
Rationale: Penicillin (e.g., piperacillin) synergizes with gentamicin against Pseudomonas by disrupting the cell wall, enhancing aminoglycoside uptake.
Question 5 of 5
A female patient is diagnosed with TB. A careful medical history should be taken because one of the drugs commonly used in TB therapy may lead to serious decrease in plasma level of concomitantly used drugs. Which drug is it?
Correct Answer: D
Rationale: Rifampicin induces CYP450, reducing plasma levels of many drugs (e.g., contraceptives, warfarin), requiring careful history.