Which of the following is not a prominent feature of Wiskott-Aldrich syndrome?

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Question 1 of 5

Which of the following is not a prominent feature of Wiskott-Aldrich syndrome?

Correct Answer: D

Rationale: Wiskott-Aldrich syndrome (WAS) features eczema, thrombocytopenia, and infections, but leukopenia is not typical; lymphocyte counts may be normal or reduced, not a prominent feature.

Question 2 of 5

A 15-month-old male child presented with thrombocytopenic purpura, atopic dermatitis, and recurrent infections caused by cytomegalovirus and P.jiroveci. Immunoglobulin assay revealed elevated IgE and IgA with decreased IgM levels. Of the following, the MOST likely diagnosis is

Correct Answer: A

Rationale: Wiskott-Aldrich syndrome is characterized by eczema, thrombocytopenia, and recurrent infections with abnormal immunoglobulin levels (elevated IgE/IgA, low IgM).

Question 3 of 5

Light microscopy of neutrophils for the presence of giant granules can help to diagnose

Correct Answer: B

Rationale: Giant granules in neutrophils are a hallmark of Chédiak-Higashi syndrome, visible under light microscopy.

Question 4 of 5

which of the following cells will be the last cell to perform its function in skin pathogen invasion

Correct Answer: B

Rationale: Naïve CD8 lymphocytes require activation by antigen-presenting cells and differentiation into cytotoxic T cells, making them the last to act compared to innate cells like NK cells, macrophages, and intraepithelial lymphocytes.

Question 5 of 5

which of the following is a Pathogen associated molecular pattern

Correct Answer: A

Rationale: Double-stranded viral RNA is a PAMP recognized by innate immune receptors like TLR3, whereas HMGb1 is a DAMP (damage-associated molecular pattern).

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