Which of the following is false regarding Burkitt's lymphoma?

Correct Answer: A

Rationale: The correct answer is A because Burkitt's lymphoma is associated with translocation of c-myc gene on chromosome 8, not chromosome 18. This translocation leads to uncontrolled cell proliferation. Choice B is incorrect because Burkitt's lymphoma commonly presents with jaw or facial bone involvement in HIV patients. Choice C is incorrect as the association between Epstein Barr infection and malaria exposure in African children increases the risk of Burkitt's lymphoma. Choice D is incorrect because Burkitt's lymphoma is histologically characterized by a 'starry sky' appearance due to macrophages engulfing apoptotic tumor cells, not due to the presence of the c-myc translocation.

Correct Answer: B

Rationale: The correct answer is B: Irradiating the blood components before transfusion. Graft versus host disease occurs when donor T-cells attack the recipient's tissues in bone marrow transplant patients. Irradiating blood components helps to deactivate T-cells in the donor blood, preventing them from attacking the recipient's tissues. Transfusion of packed cells (A) or fresh whole blood (C) does not address the issue of T-cell activation. Replacement by crystalloids (D) is not a solution for preventing graft versus host disease.

Correct Answer: C

Rationale: Rationale: A peripheral blood smear showing an increase in neutrophils, basophils, eosinophils, and platelets is indicative of Chronic Myelocytic Leukemia (CML). Neutrophils, basophils, and eosinophils are myeloid lineage cells typically elevated in CML. The presence of increased platelets is also common in CML due to the overproduction of cells in the bone marrow. Summary of other choices: A: Acute myeloid leukemia - Typically presents with a predominance of immature myeloid cells like blasts, rather than an increase in mature myeloid cells. B: Acute lymphoid leukemia - Primarily involves lymphoid lineage cells, not myeloid cells as seen in the blood smear. D: Chronic lymphocytic leukemia - Characterized by an increase in mature lymphocytes, not myeloid cells like neutrophils, basophils, and eosinophils.

Correct Answer: D

Rationale: The correct answer is D: Rapid schizonticidal activity. Artemisinin and its derivatives target the malaria parasite at the schizont stage, which is crucial for the parasite's replication and survival. By rapidly killing schizonts, these drugs help in controlling the infection and preventing severe complications. Choice A (Rapid gametocidal activity) is incorrect because artemisinin and its derivatives primarily target asexual stages of the parasite, not gametocytes. Choice B (The ability to prevent further development of hypnozoites) is incorrect as these drugs do not target the liver stages where hypnozoites develop. Choice C (Rapid sporontocidal activity) is incorrect as artemisinin derivatives do not primarily target the sexual stages of the parasite. In summary, the correct answer is D because of the drugs' effectiveness against the schizont stage, while the other choices are incorrect as they do not align with the mechanism of action of artemisinin

Correct Answer: B

Rationale: The correct answer is B: submandibular glands. Waldeyer's ring consists of a ring of lymphoid tissue in the pharynx, including the palatine tonsils (faucal tonsils), adenoids, and lingual tonsils. Submandibular glands are salivary glands located beneath the mandible and are not part of Waldeyer's ring. Therefore, B is the correct answer. Choices A, C, and D are incorrect because they are all components of Waldeyer's ring.