ATI RN
ASCP Hematology Questions Questions
Question 1 of 5
Which of the following is FALSE about factor V Leiden mutation?
Correct Answer: C
Rationale: Factor V Leiden is common (A), worse in homozygotes (B), increases venous thrombosis with OCPs (D), and causes abortions (E). Arterial thrombosis (C) is not significantly increased, making it false.
Question 2 of 5
Which of the following is least likely to be associated with prolonged thrombocytopenia in children?
Correct Answer: A
Rationale: Acute ITP (A) typically resolves within months, unlike chronic conditions SLE (B), HIV (C), type 2B vWD (D), and WAS (E), which cause prolonged thrombocytopenia.
Question 3 of 5
A 9-month-old boy appears pale. Examination reveals a palpable liver $3 \mathrm{~cm}$ below the right costal margin and palpable spleen $4 \mathrm{~cm}$ below the left costal margin. Lab findings include: hemoglobin concentration, 6.4 g/dl; mean corpuscular volume (MCV), 67 fL; and WBC, 15,000/mm3. Of the following, The MOST valuable test to confirm the diagnosis is
Correct Answer: C
Rationale: Microcytic anemia (MCV 67 fL), hepatosplenomegaly, and severe anemia at 9 months suggest thalassemia major. Hemoglobin electrophoresis (C) confirms elevated Hb F and absent Hb A, more specific than smear (A), iron studies (B), marrow (D), or US (E).
Question 4 of 5
Which of the following is not a feature of Wiskott-Aldrich Syndrome (WAS)
Correct Answer: D
Rationale: WAS includes thrombocytopenia (A), eczema (B), infections (C), and autoimmunity (D), but features small platelets, not giant (E), unlike Bernard-Soulier.
Question 5 of 5
Of the following, the LEAST likely feature of acute immune thrombocytopenia (ITP) is
Correct Answer: D
Rationale: Acute ITP features viral trigger (A), thrombocytopenia (B), bleeding (C), and marrow megakaryocytes (E). Isolated splenomegaly (D) is rare, suggesting other causes like hypersplenism.