Which of the following is a major site of immune complex deposition in systemic lupus erythematosus (SLE)?

Correct Answer: B

Rationale: The correct answer is B: Glomerular basement membrane. In SLE, immune complexes deposit in various tissues, leading to inflammation and damage. The glomerular basement membrane is a common site for immune complex deposition in SLE, resulting in lupus nephritis. The other choices are incorrect because immune complex deposition does not typically occur in the thyroid, peripheral nerves, or mast cells in SLE. Thyroid involvement in SLE is more related to autoimmune thyroiditis, while peripheral nerves are not a major site for immune complex deposition in this condition. Mast cells are primarily involved in allergic reactions and are not a major target in SLE.

Correct Answer: C

Rationale: The correct answer is C: Inform the client not to drive or sign legal papers for 24 hours. This is because belimumab can cause dizziness and fatigue as side effects, which may impair the client's ability to drive or make important decisions. It is crucial for the nurse to ensure the safety of the client and others by advising against these activities for 24 hours post-administration. Choice A: Observing the client for at least 2 hours is important for monitoring immediate adverse reactions, but it is not the most appropriate action in this scenario. Choice B: Instructing the client about the monthly infusion schedule is important for treatment adherence, but it is not the most immediate concern after the first dose administration. Choice D: Ensuring emergency equipment is working and nearby is important for safety precautions, but advising the client not to drive or sign legal papers is more directly related to the potential side effects of belimumab.

Correct Answer: D

Rationale: The correct answer is D: IFN-γ. CD4+ TH1 cells are known to primarily produce interferon-gamma (IFN-γ). This cytokine plays a crucial role in promoting cell-mediated immunity and enhancing the activity of macrophages. IL-4 (choice A) is produced by CD4+ TH2 cells and promotes humoral immunity. IL-10 (choice B) is an anti-inflammatory cytokine produced by various immune cells. IL-5 (choice C) is predominantly produced by CD4+ TH2 cells and is involved in eosinophil activation. Therefore, the main cytokine produced by CD4+ TH1 cells is IFN-γ, making choice D the correct answer.

Correct Answer: E

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: C

Rationale: The correct answer is C because avian influenza has not caused a human pandemic due to the fact that it recognizes a variant of sialic acid only found in deep tissues of humans. This unique binding preference prevents efficient human-to-human transmission, which is crucial for a pandemic to occur. Choice A is incorrect as avian flu can cause severe illness in humans. Choice B is incorrect because avian flu recognizing a variant of sialic acid found only on avian cells would not prevent a pandemic in humans. Choice D is incorrect as there is no specific annual vaccine for avian influenza.