ATI RN
Chemotherapy drugs Questions
Question 1 of 5
Which of the following is a cell wall inhibitor useful against anerobes:
Correct Answer: B
Rationale: Cefoxitin (cephalosporin) inhibits cell wall synthesis and is effective against anaerobes. Clindamycin targets protein synthesis.
Question 2 of 5
The combination of trimethoprim and sulfamethoxazole is effective against which one of the following opportunistic infections in the AIDS patient?
Correct Answer: C
Rationale: Trimethoprim-sulfamethoxazole (TMP-SMX) is effective against Toxoplasmosis, a common opportunistic infection in AIDS patients, by inhibiting folate synthesis in the parasite Toxoplasma gondii.
Question 3 of 5
The mechanism by which sulfasalazine exerts its primary action in ulcerative colitis is inhibition of
Correct Answer: B
Rationale: Sulfasalazine is metabolized in the colon to 5-aminosalicylic acid (5-ASA), which inhibits the formation of leukotrienes and prostaglandins, reducing inflammation in ulcerative colitis.
Question 4 of 5
Supplementary folinic acid may prevent anemia in folate-deficient persons who use this drug; it is a weak base, and achieves tissue levels similar to those in plasma
Correct Answer: D
Rationale: Trimethoprim inhibits dihydrofolate reductase, potentially causing folate deficiency anemia, which can be prevented with folinic acid supplementation.
Question 5 of 5
The mechanism of high - level INH resistance of M tuberculosis is
Correct Answer: B
Rationale: High-level isoniazid (INH) resistance is most commonly due to reduced expression of the katG gene, which encodes catalase-peroxidase needed to activate INH.