Which of the following immune system components would NOT recognize a macromolecule epitope (binding site)?

Correct Answer: A

Rationale: Phagocytes engulf pathogens nonspecifically and do not recognize specific epitopes, unlike T and B lymphocytes or antibodies which bind specific antigenic sites.

Correct Answer: D

Rationale: Tissue mast cells release histamine and mediators during inflammation or allergic responses, not phagocytosis or lysis.

Correct Answer: A

Rationale: The cognitive phase is the initial recognition of antigen by immune receptors.

Correct Answer: D

Rationale: Both BCRs and TCRs have immunoglobulin-like folds, unlike MHC molecules, making d (moved from e) correct.

Correct Answer: C

Rationale: An antigen binds immune receptors but doesn't always provoke a response (unlike an immunogen), making c the key differentiator.