ATI RN
Pediatric Genetic Questions
Question 1 of 5
Which of the following human triploid is possible to be found in adults:
Correct Answer: B
Rationale: Triploidy is incompatible with adult life (B). Rationale: 69, XXY (not listed) or similar triploids (3n) occur but are lethal or result in miscarriage. 92 (4n) or 23 (n) don’t fit triploidy (3n=69). Adults don’t survive triploidy.
Question 2 of 5
The shortest stage in cell cycle:
Correct Answer: A
Rationale: M phase (mitosis) is the shortest, typically 1–2 hours in a 24-hour cycle. 'A' is correct. Rationale: G1, S, and G2 (interphase) last longer (hours each), while GO is a quiescent state, not a timed phase. Mitosis is rapid, with visible stages like metaphase lasting minutes.
Question 3 of 5
Which of the following cannot used in karyotype?
Correct Answer: D
Rationale: Erythrocytes (D) cannot be used for karyotyping as they lack nuclei. Rationale: Karyotyping requires dividing cells with chromosomes; chorionic villi, lymphocytes, and bone marrow provide mitotic cells, but mature erythrocytes are enucleated.
Question 4 of 5
Protects the DNA and prevents end-to-end fusion:
Correct Answer: A
Rationale: Telomeres (A) protect chromosome ends and prevent fusion. Rationale: TTAGGG repeats cap chromosomes, stabilizing them; centromeres attach spindles, subtelomeres are adjacent but not protective.
Question 5 of 5
CML is caused by:
Correct Answer: C
Rationale: Reciprocal t(9;22) (C) causes CML (Philadelphia chromosome). Rationale: BCR-ABL1 fusion drives myeloid proliferation; Robertsonian involves acrocentrics (e.g., 14;21), not 9;22.