Which of the following factors influence the bioavailability of drugs?

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Drugs Affecting the Female Reproductive System NCLEX Quizlet Questions

Question 1 of 5

Which of the following factors influence the bioavailability of drugs?

Correct Answer: E

Rationale: It seems like there might be a mistake in the question as there is no option E provided. Nevertheless, I can provide a general rationale for the factors influencing drug bioavailability. First-pass hepatic metabolism (A) can significantly reduce bioavailability as the drug may be metabolized before reaching systemic circulation. Solubility of the drug (B) affects how easily it can dissolve and be absorbed. Chemical instability in the gastrointestinal tract (C) can lead to degradation before absorption. The nature of the drug formulation (D) can impact factors like dissolution and absorption rates. Each of these factors can influence bioavailability by affecting the amount and rate at which the drug reaches the systemic circulation.

Question 2 of 5

The nurse, working with a preconceptional couple at an infertility clinic, advises the woman to take which supplement for at least 3 months before becoming pregnant?

Correct Answer: C

Rationale: The correct answer is C: Folic acid. Folic acid is crucial for preventing neural tube defects in the fetus. Taking it before conception helps ensure adequate levels during early pregnancy. Iron is important for pregnant women but not necessarily for preconception. Ginger and Vitamin B6 do not have specific benefits related to preconception or pregnancy.

Question 3 of 5

The nurse working in labor and delivery is reviewing messages to be returned to clients. Which statement made by the client alerts the nurse to call that client first?

Correct Answer: B

Rationale: The correct answer is B because taking ibuprofen during pregnancy, especially in the third trimester like at 38 weeks, can pose risks to the baby. Ibuprofen is not recommended in late pregnancy as it can lead to complications such as premature closure of a crucial blood vessel in the baby's heart. Therefore, the nurse should call this client first to educate them on the risks and advise against taking aspirin along with ibuprofen. A: Taking calcium carbonate for heartburn during pregnancy is generally safe, so there is no urgent need to call this client first. C: Stopping folic acid at 8 weeks may not be ideal, but it is less urgent than the potential risks associated with ibuprofen in late pregnancy. D: Blood glucose of 120 mg may be normal, and the client's non-diabetic status indicates less urgency compared to the potential harm from mixing ibuprofen and aspirin during late pregnancy.

Question 4 of 5

A client is to have lumbar epidural anesthesia. Which nursing action is appropriate?

Correct Answer: C

Rationale: The correct answer is C because infusing 500 to 1000 mL of a crystalloid intravenous solution is appropriate to maintain hydration and fluid balance during lumbar epidural anesthesia. This helps prevent hypotension and supports renal function. A: Citric acid/sodium citrate is used to prevent blood clotting during dialysis, not for epidural anesthesia. B: Promethazine is an antiemetic and antihistamine, not indicated for epidural anesthesia. D: Rh0(D) immune globulin injection is used to prevent Rh incompatibility in pregnancy, not relevant to lumbar epidural anesthesia.

Question 5 of 5

Spinal anesthesia with morphine is administered to a client for pain relief during cesarean section. The client complains of itching. The nurse prepares to administer which drug?

Correct Answer: A

Rationale: Step-by-step rationale: 1. Itching post-spinal morphine is due to histamine release. 2. Diphenhydramine is an antihistamine that can relieve itching. 3. Ephedrine is a vasoconstrictor, not for itching. 4. Butorphanol is an opioid analgesic, not for itching relief. 5. Lidocaine is a local anesthetic, not for itching. Therefore, Diphenhydramine (Choice A) is the correct choice.

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