ATI RN
Central Nervous System Stimulants and Related Drugs NCLEX Style Questions Questions
Question 1 of 5
Which of the following drugs would be most appropriate for this patient to substitute for valproic acid therapy?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
Which of the following drugs was most likely prescribed for the 44-year-old woman with poorly controlled simple partial seizures that was only partially effective with valproic acid therapy?
Correct Answer: D
Rationale: The recently approved drug that acts with a novel mechanism of action, a noncompetitive blockade of AMPA receptors on brain neurons, is Perampanel. Given that the patient had poorly controlled seizures with valproic acid, adding Perampanel would provide a different mechanism of action to improve seizure control.
Question 3 of 5
Which of the following drugs would be contraindicated for this patient with cogwheel rigidity and decreased dopamine metabolism in the striatum?
Correct Answer: B
Rationale: Carbidopa is a drug that inhibits the peripheral metabolism of levodopa, allowing more levodopa to reach the brain and be converted to dopamine. In this patient with decreased dopamine metabolism in the striatum, adding carbidopa to the regimen would further enhance the availability of levodopa in the brain, thereby improving symptoms of parkinsonism. The other options do not directly address the issue of decreased dopamine metabolism in the striatum.
Question 4 of 5
A 72-year-old woman recently diagnosed with Alzheimer disease started pharmacotherapy with donepezil. Which of the following sets of adverse effects most likely occurred during the first days of treatment?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Blockade of which of the following pairs of receptors likely mediated the adverse effect of olanzapine in the 37-year-old woman with a schizoaffective disorder?
Correct Answer: B
Rationale: The most likely receptors mediating the adverse effect of olanzapine in the 37-year-old woman are GABAergic and muscarinic receptors. Olanzapine, an atypical antipsychotic, can have side effects such as acute psychotic states and aggression, which may be due to its interaction with these receptors. Blocking GABAergic receptors can lead to disinhibition and agitation, while muscarinic receptor blockade can cause cognitive impairment and confusion, both of which could contribute to the patient's acute psychotic state and aggressive behavior.