Which of the following drugs would be most appropriate to decrease the patient's symptoms before surgery for uterine fibroids?

Correct Answer: C

Rationale: The correct answer is C: Finasteride. Finasteride is a 5-alpha reductase inhibitor that can decrease the size of uterine fibroids by inhibiting the conversion of testosterone to dihydrotestosterone. This can help reduce symptoms such as heavy menstrual bleeding and pelvic pain before surgery. Ethinyl estradiol (A) is a form of estrogen and can potentially worsen fibroid symptoms. Flutamide (B) is an antiandrogen used for conditions like prostate cancer, not for uterine fibroids. Mifepristone (D) is a progesterone receptor antagonist used for medical abortion, not for managing fibroid symptoms before surgery.

Correct Answer: A

Rationale: Step 1: Cholecalciferol is the inactive form of vitamin D, which is converted to calcitriol in the body. Step 2: In a patient with vitamin D deficiency due to inadequate intake, supplementing with cholecalciferol is necessary to raise vitamin D levels. Step 3: Calcitriol (choice B) is the active form of vitamin D and is not the first-line treatment for deficiency due to inadequate intake. Step 4: Teriparatide (choice C) is a medication used for osteoporosis, not for treating vitamin D deficiency. Step 5: Cinacalcet (choice D) is used for treating hyperparathyroidism, not for vitamin D deficiency. Summary: Cholecalciferol is the appropriate choice as it directly addresses the deficiency by providing the precursor to active vitamin D, while the other choices are not indicated for this specific situation.

Correct Answer: C

Rationale: The correct answer is C: Pamidronate. This drug is used in the management of conditions like hypercalcemia, Paget's disease, and osteoporosis, which are commonly associated with cancer patients. It inhibits bone resorption and helps lower calcium levels. Sodium phosphate (A) is a laxative, not indicated for this patient. Hydrochlorothiazide (B) is a diuretic used for hypertension, not for managing the conditions mentioned. Mannitol (D) is an osmotic diuretic mainly used for reducing intracranial pressure, not indicated in this case. Pamidronate is the best choice due to its mechanism of action and relevance to the patient's condition.

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.