ATI RN
Central Nervous System Stimulants and Related Drugs NCLEX Style Questions Questions
Question 1 of 5
Which of the following drugs was most likely prescribed for the 44-year-old woman with poorly controlled simple partial seizures that was only partially effective with valproic acid therapy?
Correct Answer: D
Rationale: The recently approved drug that acts with a novel mechanism of action, a noncompetitive blockade of AMPA receptors on brain neurons, is Perampanel. Given that the patient had poorly controlled seizures with valproic acid, adding Perampanel would provide a different mechanism of action to improve seizure control.
Question 2 of 5
In the treatment of congenital adrenal hyperplasia in which there is excess production of cortisol precursor, the purpose of administration of synthetic glucocorticoid is:
Correct Answer: D
Rationale: In CAH (choice D), synthetic glucocorticoids suppress ACTH, reducing adrenal precursor excess (e.g., 17-hydroxyprogesterone). Aldosterone (choice A), renal (choice B), and immune (choice C) effects aren't primary goals. ACTH suppression corrects the defect.
Question 3 of 5
Phenytoin sodium
Correct Answer: A
Rationale: Phenytoin is used in arrhythmias to suppress ventricular automaticity without significantly affecting AV conduction.
Question 4 of 5
Which of the recently introduced antiepileptics is useful in absence seizure?
Correct Answer: A
Rationale: Newer antiepileptic drugs like ethosuximide and valproate are effective in treating absence seizures which are generalized brief and involve loss of consciousness.
Question 5 of 5
All of the following medications should be avoided in the third trimester of pregnancy, except
Correct Answer: A
Rationale: Acetaminophen is considered safe during pregnancy, while NSAIDs, warfarin, lithium, and aspirin pose risks in the third trimester.