Which of the following drugs was most likely prescribed for the 44-year-old woman with poorly controlled simple partial seizures that was only partially effective with valproic acid therapy?

Correct Answer: D

Rationale: The recently approved drug that acts with a novel mechanism of action, a noncompetitive blockade of AMPA receptors on brain neurons, is Perampanel. Given that the patient had poorly controlled seizures with valproic acid, adding Perampanel would provide a different mechanism of action to improve seizure control.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: The most likely receptors mediating the adverse effect of olanzapine in the 37-year-old woman are GABAergic and muscarinic receptors. Olanzapine, an atypical antipsychotic, can have side effects such as acute psychotic states and aggression, which may be due to its interaction with these receptors. Blocking GABAergic receptors can lead to disinhibition and agitation, while muscarinic receptor blockade can cause cognitive impairment and confusion, both of which could contribute to the patient's acute psychotic state and aggressive behavior.

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.