Which of the following drugs valuable in the treatment of edema and * metabolic alkalosis?

Correct Answer: D

Rationale: The correct answer is D: Acetazolamide. Acetazolamide is a diuretic that inhibits carbonic anhydrase enzyme, leading to increased excretion of bicarbonate ions, thus causing metabolic alkalosis correction and reducing edema. Digoxin (A) is used for heart failure, Spironolactone (B) is a potassium-sparing diuretic, and Dobutamine (C) is a beta-adrenergic agonist used for heart failure, none of which directly address metabolic alkalosis.

Correct Answer: D

Rationale: Spironolactone is a potassium-sparing diuretic, so combining it with another potassium-sparing diuretic like amiloride can lead to hyperkalemia. Chlorthalidone, a thiazide-like diuretic, can be synergistic with spironolactone. Furosemide, a loop diuretic, can counteract the potassium-sparing effects of spironolactone. Hydrochlorothiazide, a thiazide diuretic, can also lead to hypokalemia when combined with spironolactone. Therefore, the correct answer is D, as combining spironolactone with hydrochlorothiazide may increase the risk of potassium imbalance.

Correct Answer: A

Rationale: The correct answer is A: ADH plays a key role in the homeostatic filtration apparatus called the process called osmoregulation. ADH, or antidiuretic hormone, regulates water balance by controlling the permeability of the collecting duct in the kidney nephrons. This controls the concentration of urine produced. The other choices, B and C, refer to specific parts of the kidney tubules and are not related to the role of ADH in osmoregulation. Choice D is incomplete and does not provide any relevant information. Therefore, A is the correct choice as it directly relates to the function of ADH in maintaining water balance within the body.

Correct Answer: B

Rationale: The correct answer is B because the antibiotic regimen for acute uncomplicated pyelonephritis should not include gentamycin due to its potential toxicity and nephrotoxicity. The initial use of IV gentamycin is not recommended for uncomplicated pyelonephritis. The combination of gentamycin and amoxicillin is not the standard treatment for this condition. Gentamycin should be reserved for more serious infections. The choice of Augmentin for 7 days orally is also not the standard of care for pyelonephritis. The other choices (A, C, D) are appropriate antibiotic regimens for the corresponding clinical scenarios.

Correct Answer: A

Rationale: The correct answer is A: calcium oxalate. This is because calcium oxalate stones are the most common type of ureteric calculus, accounting for around 75% of cases. They form due to an excess of calcium and oxalate in the urine. Triple phosphate stones (choice B) are more commonly found in the bladder and are associated with urinary tract infections. Urate stones (choice C) are less common and typically seen in patients with gout or acidic urine. Cysteine stones (choice D) are rare and usually seen in patients with a genetic disorder affecting cysteine metabolism.