ATI RN
ATI Pharmacology Study Guide PDF Questions
Question 1 of 9
Which of the following drugs used in cancer chemotherapy is most likely to be associated with cerebellar dysfunction?
Correct Answer: A
Rationale: Chemotherapy neurotoxicity varies. Cytarabine, at high doses, causes cerebellar ataxia and dysarthria via Purkinje cell damage, most likely here. Cyclophosphamide risks hemorrhagic cystitis, mitoxantrone cardiotoxicity, bleomycin lung fibrosis, and vincristine peripheral neuropathy, not cerebellar issues. Cytarabine's CNS penetration drives this toxicity, requiring dose monitoring in leukemia treatment.
Question 2 of 9
A 31-year-old male patient has been prescribed propranolol to reduce and prevent angina. What will the nurse assess this patient for related to the medication? (Select all that apply.)
Correct Answer: B
Rationale: Adverse effects of propranolol that the nurse would assess for include allergic reaction, bradycardia, heart failure, cardiac arrhythmias, cerebrovascular accident, pulmonary edema, gastric pain, flatulence, impotence, decreased exercise tolerance, and bronchospasm. The nurse should monitor for these adverse effects and intervene as needed to ensure patient safety.
Question 3 of 9
A patient is beginning isoniazid and rifampin treatment for tuberculosis. The nurse gives the patient which instruction?
Correct Answer: A
Rationale: Adherence to the prescribed regimen is critical in tuberculosis treatment to prevent resistance and ensure efficacy. Skipping doses can lead to treatment failure and drug-resistant TB. Isoniazid and rifampin are typically taken once daily, not three times daily. Antacids can interfere with the absorption of these drugs and should be avoided. There is no specific requirement to take rifampin initially; both drugs should be taken as prescribed.
Question 4 of 9
Which medication is a glutamate receptor antagonist that can be used in combination with an acetylcholinesterase inhibitor to manage the symptoms of Alzheimer's disease?
Correct Answer: D
Rationale: Memantine, an NMDA glutamate receptor antagonist, manages Alzheimer's by reducing excitotoxicity from excessive glutamate, which contributes to neuronal damage in later stages. It complements acetylcholinesterase inhibitors (e.g., donepezil), which boost cholinergic function for memory, by targeting a different pathway, slowing progression and improving behavior. Rivastigmine and donepezil are acetylcholinesterase inhibitors, not glutamate antagonists. Ropinirole, a dopamine agonist, treats Parkinson's. Fluoxetine, an SSRI, addresses depression. Memantine's unique glutamate modulation, combined with cholinergic enhancement, offers a dual approach, supported by evidence for moderate-to-severe Alzheimer's management.
Question 5 of 9
The nurse is obtaining a medication history on a patient presenting with chest pain. What drug classification would necessitate the nurse informing the provider before beginning the prescribed nitroglycerin?
Correct Answer: B
Rationale: Phosphodiesterase inhibitors (Erectile Dysfunction medications) are contraindicated with nitroglycerin due to the potential for severe hypotension and cardiovascular collapse when taken together. It is essential for the nurse to inform the provider before administering nitroglycerin if the patient is taking phosphodiesterase inhibitors to prevent any harmful interactions.
Question 6 of 9
A mother brings her 4-year-old son to the emergency department after discovering him eating her iron supplement. Which of the following should be administered to chelate the excess iron in his body?
Correct Answer: B
Rationale: Iron overdose in a child requires a specific chelator. Deferoxamine binds ferric iron, forming ferrioxamine, excreted renally. EDTA chelates calcium and lead, not iron-specific. Dimercaprol treats heavy metals like arsenic, not iron. Penicillamine is for copper (Wilson's disease). Succimer (E) targets lead. Deferoxamine's high affinity for iron makes it standard for acute toxicity, preventing organ damage (e.g., liver, heart), critical in this pediatric emergency.
Question 7 of 9
The number of people with hypertension in the United States is estimated to be
Correct Answer: B
Rationale: The estimated number of people with hypertension in the United States is around 25 million. Hypertension, commonly known as high blood pressure, is a prevalent health condition affecting a significant portion of the population. This estimate is based on data collected from various healthcare sources and studies on the prevalence of hypertension in the country. It is important to monitor and manage hypertension effectively to prevent the associated health risks, such as heart disease and stroke.
Question 8 of 9
While assessing a patient who is receiving intravenous digitalis, the nurse recognizes that the drug has a negative chronotropic effect. How would this drug effect be evident in the patient?
Correct Answer: B
Rationale: Digitalis is a medication commonly used to treat heart failure and certain cardiac arrhythmias. It works by increasing the force of heart contractions and slowing down the heart rate. Digitalis has a negative chronotropic effect, which means it decreases the heart rate by affecting the electrical conduction system of the heart. When a patient is receiving intravenous digitalis, a decreased heart rate would be evident as a result of this pharmacological action. Therefore, the correct answer is B. Decreased heart rate.
Question 9 of 9
Which of the following drugs used in cancer chemotherapy is most likely to be associated with cerebellar dysfunction?
Correct Answer: A
Rationale: Chemotherapy neurotoxicity varies. Cytarabine, at high doses, causes cerebellar ataxia and dysarthria via Purkinje cell damage, most likely here. Cyclophosphamide risks hemorrhagic cystitis, mitoxantrone cardiotoxicity, bleomycin lung fibrosis, and vincristine peripheral neuropathy, not cerebellar issues. Cytarabine's CNS penetration drives this toxicity, requiring dose monitoring in leukemia treatment.