ATI RN
Chemotherapy drugs Questions
Question 1 of 5
Which of the following drugs is penicillinase-resistant and given orally?
Correct Answer: C
Rationale: Penicillin V is penicillinase-resistant and oral, effective against streptococci. Ampicillin and amoxicillin are broader-spectrum, and Augmentin includes clavulanate.
Question 2 of 5
The main reason for the limited use of chloramphenicol is high incidence of:
Correct Answer: A
Rationale: Chloramphenicol’s rare but severe aplastic anemia limits its use, outweighing other side effects like hepatotoxicity.
Question 3 of 5
A patient on warfarin therapy developed a chest infection for which he took antibacterial therapy. He suffered from bleeding. The antimicrobial taken most probably was:
Correct Answer: A
Rationale: Co-trimoxazole inhibits warfarin metabolism (CYP2C9), increasing INR and bleeding risk, unlike aztreonam, rifampicin (inducer), or gentamicin.
Question 4 of 5
In the previous case, this adverse effect can be avoided by:
Correct Answer: B
Rationale: Pretreating with antihistamines reduces vancomycin-induced histamine release, preventing flushing.
Question 5 of 5
A patient with a Pseudomonas aeruginosa infection is receiving IV gentamycin, but the clinical response is not satisfactory. If penicillin is administered in a separate IV line to avoid physical interaction, which of the following will occur?
Correct Answer: C
Rationale: Penicillin (e.g., piperacillin) synergizes with gentamicin against Pseudomonas by disrupting the cell wall, enhancing aminoglycoside uptake.