ATI RN
ATI Pharmacology Practice B 2023 Questions
Question 1 of 5
Which of the following drugs is most useful for the treatment of absence seizures?
Correct Answer: D
Rationale: Lamotrigine, a broad-spectrum antiepileptic, treats absence seizures by stabilizing sodium channels and inhibiting glutamate release, though less specific than ethosuximide. Topiramate and levetiracetam manage multiple seizure types but aren't first-line for absence. Tiagabine, a GABA reuptake inhibitor, may worsen absence seizures. Zonisamide has broad efficacy but less absence focus. While ethosuximide is gold standard, lamotrigine's utility in absence, especially in mixed epilepsies, and clinical evidence make it the most useful here among options.
Question 2 of 5
A 29-year-old woman has a positive pregnancy test. She presents to her primary care physician for confirmation. She has a history of recurrent urinary tract infections, headaches, seizure disorder, and pulmonary embolus. Her current medications include acetaminophen, ciprofloxacin, warfarin, valproic acid, and methotrexate. Which of the following medications could be maintained at its current dose during her pregnancy?
Correct Answer: A
Rationale: Pregnancy limits medication safety. Acetaminophen is safe, used for pain with minimal fetal risk. Ciprofloxacin risks cartilage damage. Methotrexate and Valproic acid are teratogenic. Warfarin (E) causes fetal bleeding. Acetaminophen's profile suits her needs.
Question 3 of 5
A neighbor tells nurse Maureen he has to have surgery and is reluctant to have any blood product transfusions because of a fear of contracting an infection. He asks the nurse what are his options. The nurse teaches the person that the safest blood product is:
Correct Answer: C
Rationale: An autologous blood product is the safest option because it involves the patient donating their own blood before surgery, eliminating the risk of transfusion reactions or infections from donor blood. Allogeneic products come from other donors and carry a small risk of infection or incompatibility. Directed donations are from known donors but still carry some risks. Cross-matching ensures compatibility but does not eliminate infection risks. Therefore, autologous donation is the safest choice.
Question 4 of 5
Which of the following describes the relationship of the blood concentration attained with initial dosing and the dose of drug given
Correct Answer: C
Rationale: The relationship of the blood concentration attained with initial dosing and the dose of drug given is best described by the concept of steady state. Steady state refers to the point at which the rate of drug input (dose) equals the rate of drug elimination, resulting in consistent drug levels in the blood. Achieving steady state typically requires several half-lives of the drug, during which the drug concentration gradually increases with each dose until it stabilizes. The dose of the drug given will influence how quickly steady state is reached and at what concentration the drug will be maintained in the body. Factors such as bioavailability, half-life, volume of distribution, and clearance play important roles in determining the dosage needed to reach and maintain steady state drug levels in the body.
Question 5 of 5
A 19-year-old man attempts suicide after failing all of his college courses. He goes home and takes more than 90 digoxin tablets (0.25 mg each), ingesting them about 3 h prior to presentation at the emergency department. He is brought to the hospital by his brother. Vital signs are as follows: pulse is 50 beats/minute, and the electrocardiogram indicates third-degree heart block. Serum electrolytes are normal. Which of the following is the most important therapy to initiate in this patient?
Correct Answer: B
Rationale: Digoxin overdose (bradycardia, heart block) requires digoxin immune Fab , binding free digoxin to reverse toxicity. Amiodarone and lidocaine treat arrhythmias but not the cause. Potassium and verapamil (E) worsen hyperkalemia or block. Fab is urgent here.