Which of the following drugs is least likely to cause thrombocytopenia in children?

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Question 1 of 5

Which of the following drugs is least likely to cause thrombocytopenia in children?

Correct Answer: B

Rationale: Phenytoin (B) rarely causes thrombocytopenia, unlike valproic acid (A), sulfonamides (C), TMP-SMX (D), and heparin (E), which are well-known culprits.

Question 2 of 5

A 5-year-old child has multiple bruises on her extremities and oral mucosal bleeding of 3 days duration; she had a mild respiratory tract infection 2 weeks before; physical examination was normal apart from multiple ecchymoses and petechiae. Of the following, the NEXT diagnostic step is

Correct Answer: A

Rationale: Post-viral bruising and mucosal bleeding suggest ITP. CBC (A) confirms thrombocytopenia, the next step before PT (B), BT (C), PTT (D), or ANA (E), which assess other causes.

Question 3 of 5

A 3-year-old male child develops hematoma and bruising of his right hand next day after falling on the ground; the mother stated that her child has a poor wound healing and a history of delayed umbilical separation during the neonatal period. Of the following, the MOST valuable test for this case is

Correct Answer: D

Rationale: Bruising, poor healing, and delayed umbilical separation suggest factor XIII deficiency. Clot solubility test (E) screens for this, more specific than BT (A), PTT (B), PT (C), or TT (D).

Question 4 of 5

Which of the following is the best treatment for a 5-year-old girl with acute immune thrombocytopenia (ITP) and platelets count of $30,000 / \mathrm{ml}$ and mild petechial rash all over her body?

Correct Answer: D

Rationale: Acute ITP with platelets 30,000/mL and mild petechiae often resolves spontaneously (E), especially without severe bleeding, unlike IVIG (A), anti-D (B), steroids (C), or transfusion (D).

Question 5 of 5

It is a common complication after an open heart surgery due to immunological phenomena with up to 30% of cardiac surgery. Treatment is usually with anti-inflammatory medications and colchicine.

Correct Answer: C

Rationale: Postpericardiotomy syndrome (C) occurs in up to 30% of cardiac surgeries, treated with anti-inflammatories and colchicine, fitting the description.

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