Which of the following drugs is associated with the reaction of Cinchonism?

Correct Answer: B

Rationale: The correct answer is B: Quinidine. Cinchonism is a condition caused by the toxicity of Cinchona alkaloids, which are found in drugs like quinine and quinidine. Quinidine is specifically known to cause symptoms of cinchonism such as tinnitus, headache, blurred vision, and nausea. Valproic acid (choice A) is an anticonvulsant, not associated with cinchonism. Isoniazid (choice C) is an antibiotic used to treat tuberculosis and does not cause cinchonism. Ethosuximide (choice D) is an anticonvulsant used to treat absence seizures and is not linked to cinchonism.

Correct Answer: D

Rationale: Step 1: Ethosuximide is the correct answer as it is a known trigger for Stevens-Johnson syndrome due to its association with hypersensitivity reactions. Step 2: Valproic acid can cause liver toxicity but is not typically linked to Stevens-Johnson syndrome. Step 3: Quinidine is associated with drug-induced lupus but not commonly known to cause Stevens-Johnson syndrome. Step 4: Isoniazid is linked to drug-induced hepatitis but not typically associated with Stevens-Johnson syndrome. In summary, Ethosuximide is the correct choice due to its well-documented association with Stevens-Johnson syndrome, while the other options are linked to different adverse effects.

Correct Answer: D

Rationale: The correct answer is D: Fluoroquinolones. Fluoroquinolones are known to be associated with tendon dysfunction due to their potential to cause tendinitis and tendon rupture. This adverse effect is thought to be related to the drug's ability to disrupt collagen synthesis and structure in tendons. Digitalis (A) is used to treat heart conditions, niacin (B) for cholesterol, and tetracycline (C) for bacterial infections, none of which are linked to tendon dysfunction.

Correct Answer: B

Rationale: The correct answer is B: ACE inhibitor. Drugs ending in the suffix (-pril) typically refer to ACE inhibitors, which are commonly used to treat hypertension and heart failure by inhibiting the angiotensin-converting enzyme. ACE inhibitors do not belong to the categories mentioned in the other choices. Choice A (H) is vague and does not provide any relevant information. Choice C (Antifungal) is incorrect as drugs ending in (-pril) are not typically used to treat fungal infections. Choice D (Beta agonist) is also incorrect as drugs ending in (-pril) do not belong to the class of beta agonists, which are used to treat conditions like asthma and COPD.

Correct Answer: C

Rationale: The correct answer is C: Antifungal. Drugs ending in the suffix (azole) are commonly used to treat fungal infections. The suffix indicates that the drug belongs to the azole class, which specifically targets fungal pathogens by inhibiting their growth. Therefore, a drug ending in (azole) is classified as an antifungal medication. Summary of other choices: A: H - Incorrect. There is no pharmacological relevance to the suffix (azole) in relation to the letter H. B: ACE inhibitor - Incorrect. Drugs ending in (pril) are commonly ACE inhibitors, not those ending in (azole). D: Beta agonist - Incorrect. Drugs ending in (ol) or (olol) are typically beta agonists, not those ending in (azole).