ATI RN
ATI Pharmacology Test Bank Questions
Question 1 of 5
Which of the following drugs causes the most significant inhibition of metabolism of rifabutin?
Correct Answer: B
Rationale: Rifabutin, metabolized by CYP3A4, is affected by inhibitors. Zidovudine, enfuvirtide, and nevirapine don't strongly inhibit CYP3A4. St John's wort induces it, lowering levels. Ritonavir, a potent CYP3A4 inhibitor, significantly slows rifabutin metabolism, raising levels and toxicity risk (e.g., uveitis), the most impactful. This interaction requires dose adjustment, critical in HIV-TB co-treatment.
Question 2 of 5
The nurse is teaching a class for clients about over-the-counter (OTC) medications. The nurse determines that education has been effective when the clients make which statement?
Correct Answer: C
Rationale: Reading OTC labels and seeking clarification from a doctor if unclear ensures safe use, reflecting effective education on responsibility. Always calling the doctor is overly cautious-OTC drugs are for self-management. Pharmacists help, but label-reading is primary. Assuming OTC safety ignores risks like ibuprofen's bleeding potential. Label focus empowers clients, balancing autonomy with safety, a key learning outcome.
Question 3 of 5
Mark the location of the beginning of the plateau phase on this dose-response relationship curve.
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
The nurse has completed medication education with the patient who is receiving lithium (Eskalith). What is the priority patient outcome?
Correct Answer: B
Rationale: Lithium toxicity (e.g., tremors, confusion) at narrow therapeutic range (0.6-1.2) is life-threatening-knowing signs (e.g., nausea) and prevention (e.g., hydration) is priority, per safety. Work, ADLs, and mood stability follow but aren't immediate risks. Toxicity awareness saves lives, per education.
Question 5 of 5
A 34-year-old man is a chronic alcoholic and is in and out of a rehabilitation center on a monthly basis. His physician administers a blocker of aldehyde dehydrogenase. Which of the following effects is most likely to be exhibited by this patient following administration?
Correct Answer: D
Rationale: Disulfiram, an aldehyde dehydrogenase blocker, is used in alcoholism to deter drinking. When alcohol is consumed, acetaldehyde accumulates, causing nausea . Bradycardia isn't typical; tachycardia may occur with acetaldehyde buildup. Elation and euphoria contradict the aversive intent. Urticaria (E) is possible but less common. Nausea, with flushing and vomiting, creates an unpleasant reaction, reinforcing abstinence. This aligns with disulfiram's mechanism, leveraging acetaldehyde toxicity to modify behavior, distinguishing it from other effects.