ATI RN
CNS Drugs Pharmacology Questions
Question 1 of 5
Which of the following drugs acts as a competitive benzodiazepine receptor antagonist:
Correct Answer: B
Rationale: A competitive benzodiazepine receptor antagonist binds to the GABAa receptor's benzodiazepine site, preventing agonists like diazepam from exerting effects, without activating the receptor itself. Flumazenil is this antagonist, used to reverse benzodiazepine overdose (e.g., reversing sedation or respiratory depression) by competitively displacing agonists. Naloxone (choice A) is an opioid antagonist, targeting mu receptors to reverse opioid overdose, not benzodiazepine-related. Flurazepam (choice C) is a benzodiazepine agonist, promoting GABA effects, not blocking them. Disulfuram (choice D, likely misspelled) inhibits aldehyde dehydrogenase for alcoholism treatment, unrelated to benzodiazepine receptors. Flumazenil's specificity and competitive nature make it the correct choice. This question emphasizes antidote recognition, critical in emergency settings to counteract CNS depression, distinguishing it from other reversal agents like Naloxone.
Question 2 of 5
The following is a selective serotonin reuptake inhibitor used in treatment of psychic depression:
Correct Answer: C
Rationale: Fluoxetine (choice C), an SSRI, treats depression by selectively inhibiting serotonin reuptake, increasing synaptic levels. Imipramine (choice A) and Amitriptyline (choice B), tricyclic antidepressants, block multiple transmitters, not just serotonin. Maprotiline (choice D), a tetracyclic, primarily affects norepinephrine. Fluoxetine's specificity reduces side effects, making it a cornerstone in depression therapy.
Question 3 of 5
The following statements are correct about MAO inhibitors EXCEPT:
Correct Answer: C
Rationale: MAO inhibitors (MAOIs) raise monoamine levels by blocking their breakdown (choice D), risking hypertensive crisis with tyramine-rich foods (choice A). Selegiline (choice B) selectively inhibits MAO-B. However, combining MAOIs with SSRIs (choice C) causes serotonin syndrome, a dangerous interaction, not a useful synergy, making it the wrong statement. This highlights critical drug interaction knowledge.
Question 4 of 5
Side effects of benzodiazepines include the following EXCEPT:
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Narcotic analgesics include which of the following:
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.