Which of the following drug used in the treatment of filariasis? *

Correct Answer: A

Rationale: Diethyl carbamazine is the correct answer for the treatment of filariasis as it is the drug of choice due to its effectiveness in killing microfilariae and adult worms. Diethyl carbamazine directly targets the parasites responsible for filariasis, leading to their death and eventual elimination from the body. Albendazole, Levamisole, and Piperazine are not commonly used for filariasis treatment and are more commonly used for other parasitic infections. Albendazole is more commonly used for helminthic infections, Levamisole for roundworm infections, and Piperazine for pinworm infections.

Correct Answer: A

Rationale: Acyclovir is a nucleoside analog that inhibits viral DNA replication by targeting viral DNA polymerase. Herpes simplex Type 1 virus is most susceptible to acyclovir because it is a DNA virus that requires viral DNA polymerase for replication. The drug is selectively activated by viral thymidine kinase in infected cells, leading to its antiviral activity. Herpes simplex Type 2, Varicella zoster, and other viruses do not possess the same susceptibility to acyclovir due to differences in their replication mechanisms.

Correct Answer: B

Rationale: The correct answer is B: Tinidazole. This drug is used for oral treatment of trichomonas vaginitis due to its high efficacy against the parasite. Tinidazole is a nitroimidazole antibiotic that targets anaerobic organisms like Trichomonas vaginalis. Diiodohydroxyquin (A) is used for amoebiasis, not trichomonas. Clotrimazole (C) and Ketoconazole (D) are antifungal medications and not effective against trichomonas parasites.

Correct Answer: C

Rationale: Step 1: Clofazimine is the correct answer because it is known to suppress both lepra reaction and reversal reaction in leprosy treatment. Step 2: Dapsone is mainly used to treat leprosy but does not specifically target lepra reaction. Step 3: Rifampin is effective against leprosy but does not have a direct impact on lepra reactions. Step 4: Minocycline can be used in leprosy treatment but does not have the same dual action as clofazimine.

Correct Answer: D

Rationale: The correct answer is D: Acetazolamide. Acetazolamide is a diuretic that inhibits carbonic anhydrase enzyme, leading to increased excretion of bicarbonate ions, thus causing metabolic alkalosis correction and reducing edema. Digoxin (A) is used for heart failure, Spironolactone (B) is a potassium-sparing diuretic, and Dobutamine (C) is a beta-adrenergic agonist used for heart failure, none of which directly address metabolic alkalosis.